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Kazinol B

Catalog No. T20232 CAS 99624-27-8

Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activating the insulin-Akt signalling pathway and AMPK, which enhances glucose uptake.Kazinol B stimulates gene expression and secretion of adiponectin and can be used to study diabetes.

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Kazinol B, CAS 99624-27-8

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Description

In vitro

Kazinol B (2-20 μM ; 5 days) dose-dependently increases PPARγ and C/EBPα protein and mRNA levels in MDI-treated 3T3-L1 adipocytes.[1]
Kazinol B (10-20 μM ; pre-treated for 1 h followed by 1 h insulin) dose-dependently increases insulin-dependent Akt phosphorylation.[1]
Kazinol B (2, 10 and 20 μM ; 72 hours) shows no toxicity to adipocytes in 3T3-L1 cells.[1]
Kazinol B (2-20 μM ; 72 hours) dose-dependently increases lipid accumulation by 2.4-fold (at 20 μM) treatment as compared with MDI-treated cells.[1]
Kazinol B (2-20 μM ; 24 hours) increases the retained 2ʹNBDG-fluorescence in cells in a dose-dependent manner in differentiated 3T3-L1 adipocytes and C2C12 myoblasts.[1] Kazinol B dependently increases the MDI-stimulated GLUT4 mRNA level up to 4.7-fold as compared with MDI-only treated cells.[1]
Kazinol B (6.25, 12.5, 25, 50 μM ; 18 hours) dose-dependently reduces amounts of iNOS protein in macrophages (RAW 264.7 cells) activated by LPS (1 ug/mL).[2]

Molecular Weight	392.49
Formula	C25H28O4
CAS No.	99624-27-8

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Lee H, et al. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 ; 112:90-6. 2. Ryu JH, et al. Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. Fitoterapia. 2003 Jun ; 74(4):350-354. 3. Wang JP, et al. The signal transduction mechanism involved in kazinol B-stimulated superoxide anion generation in rat neutrophils. Br J Pharmacol. 1998 ; 125(3):517-525. 4. Wang JP, et al. Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2004 ; 370(6):500-509. 5. Lee H, et al. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 ; 112:90-96.

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Keywords

Kazinol B 99624-27-8 Chromatin/Epigenetic Cytoskeletal Signaling Immunology/Inflammation PI3K/Akt/mTOR signaling Akt AMPK NO Synthase inhibitor inhibit

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