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Isoproterenol

Catalog No. T21411 CAS 7683-59-2

Synonyms: Norisodrine, Isoprenaline, Novodrin, Isuprel, Medihaler-Iso

Isoproterenol (Norisodrine) is a non-selective and orally active β-adrenoceptor agonist.Isoproterenol is a potent peripheral vasodilator and bronchodilator.Isoproterenol can be used in the study of bradycardia and bronchial asthma for the treatment of heart block, bradycardia.

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Isoproterenol, CAS 7683-59-2

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 350.00
5 mg	Inquiry	$ 828.00
10 mg	Inquiry	$ 1,130.00
25 mg	Inquiry	$ 1,590.00
50 mg	Inquiry	$ 2,130.00

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Description	Isoproterenol (Norisodrine) is a non-selective and orally active β-adrenoceptor agonist.Isoproterenol is a potent peripheral vasodilator and bronchodilator.Isoproterenol can be used in the study of bradycardia and bronchial asthma for the treatment of heart block, bradycardia.
In vitro	Isoproterenol (300 nM, 3 minutes) increased the activity of low-Km cAMP Phosphodiesterase (cAMP PDE) inhibited by granule cGMP and cilotamide by about 100% in intact rat adipocytes.[1] Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current. Isoprenaline increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit-isolated pacemaker cells.[5]
In vivo	Isoproterenol (0.27-0. 64 μg/kg; oral; dog) is widely metabolized in dogs through relatively small amounts of reactions.[6]

Synonyms	Norisodrine, Isoprenaline, Novodrin, Isuprel, Medihaler-Iso
Molecular Weight	211.26
Formula	C11H17NO3
CAS No.	7683-59-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: Insoluble

References and Literature

1. Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990;87(2):533-537. 2. Nichtova Z, et al. Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol. Gen Physiol Biophys. 2012 Jun;31(2):141-51. 3. Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase Br J Pharmacol. 1996;119(3):471-478. 4. Müller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993;72(3):696-700. 5. Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000;85(1):27-35. 6. Conolly ME, et al. Metabolism of isoprenaline in dog and man. Br J Pharmacol. 1972;46(3):458-472. 7. Yu C, et al. Cardioprotective effect of ocotillol, a derivate of pseudoginsenoside F11, on myocardial injury induced by isoproterenol in rats. Arzneimittelforschung. 2007;57(9):568-572.

Citations

1. Chen S, Zhou X, Li W, et al.Development of a novel peptide targeting GPR81 to suppress adipocyte-mediated tumor progression.Biochemical Pharmacology.2023: 115800.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library EMA Approved Drug Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Isoproterenol 7683-59-2 GPCR/G Protein Metabolism Neuroscience Endogenous Metabolite Adrenergic Receptor Norisodrine Isoprenaline Novodrin Isuprel Medihaler-Iso inhibitor inhibit

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