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Acetyl-L-carnitine

Catalog No. T26551 CAS 3040-38-8

Synonyms: RO 447190, L-Acetylcarnitine, LAC, L-O-Acetylcarnitine, ALCAR, Acetyl L carnitine

Acetyl-L-carnitine(RO 447190) is an amino acid that crosses the blood-brain barrier and is often used as a dietary supplement for neuroinflammation.Acetyl-L-carnitine is neuroprotective and can be used in the study of neurological disorders like Alzheimer's disease.

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Acetyl-L-carnitine, CAS 3040-38-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 258.00
5 mg	In stock	$ 642.00
10 mg	In stock	$ 913.00
25 mg	In stock	$ 1,370.00
50 mg	In stock	$ 1,850.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 100%

Biological Description

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Storage & Solubility Information

Description

In vivo

Three different paradigms were used to deliver Acetyl L-carnitine (ALCAR) to aging Fischer 344/NHsd rats. Rats in each condition had their hearing evaluated by auditory brainstem responses before, during, and after treatment. First, 24-month-old rats were given ALCAR (100 mg/kg dissolved 25 mg/ml in saline) by IP injection daily for one month. Second, 18-month-old rats were given ALCAR (100 mg/kg) by oral gavage for 90 days. Third, 15-month-old rats were given ALCAR (100 mg/kg) by oral gavage for 90 days. Control rats in each condition received saline by i.p. injection or gavage. The current study does not provide evidence that age-related hearing loss in the Fischer 344/NHsd rat can be altered with systemic administration of ALCAR.[2]

Synonyms	RO 447190, L-Acetylcarnitine, LAC, L-O-Acetylcarnitine, ALCAR, Acetyl L carnitine
Molecular Weight	203.24
Formula	C9H17NO4
CAS No.	3040-38-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.03 mg/mL(10 mM ), Sonication is recommended.

H2O: 2.03 mg/mL(10 mM), Sonication is recommended.

References and Literature

1. Pourshahidi S, et al. The Effect of Acetyl-L-Carnitine (ALCAR) on Peripheral Nerve Regeneration in Animal Models: A Systematic Review. Neurochem Res. 2023 Aug;48(8):2335-2344. 2. Bielefeld EC, et al. Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat. J Negat Results Biomed. 2008 Jul 11;7:4. 3. Grondin Y, et al. Pulmonary delivery of d-methionine is associated with an increase in ALCAR and glutathione in cochlear fluids. Hear Res. 2013 Apr;298:93-103. 4. Singh S, et al. ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats. Mol Neurobiol. 2016 Sep;53(7):4286-301.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library Approved Drug Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library

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Keywords

Acetyl-L-carnitine 3040-38-8 Metabolism Endogenous Metabolite RO 447190 RO-447190 L-Acetylcarnitine RO447190 LAC L-O-Acetylcarnitine ALCAR Acetyl L carnitine inhibitor inhibit

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