Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 48.00 | |
10 mg | In stock | $ 74.00 | |
25 mg | In stock | $ 163.00 | |
50 mg | In stock | $ 266.00 | |
100 mg | In stock | $ 395.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 93.00 |
Description | IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
Targets&IC50 | GluR1:6 μM |
In vitro | IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. [1] IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization. [2] |
Synonyms | IEM 1754 dihydrobromide |
Molecular Weight | 412.25 |
Formula | C16H30N2·2HBr |
CAS No. | 162831-31-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 75 mg/mL (181.9 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 76 mg/mL (184.4 mM)
You can also refer to dose conversion for different animals. More
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IEM 1754 2HBr 162831-31-4 Neuroscience GluR AMPA receptor channel block IEM1754 IEM 1754 Ionotropic glutamate receptors voltage dependence IEM-1754 IEM1754 Dihydrobromide inhibit iGluR Inhibitor IEM 1754 dihydrobromide NMDA receptor IEM 1754 Dihydrobromide IEM-1754 Dihydrobromide inhibitor