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IEM 1754 2HBr

Catalog No. T6134   CAS 162831-31-4
Synonyms: IEM 1754 dihydrobromide

IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.

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IEM 1754 2HBr Chemical Structure
IEM 1754 2HBr, CAS 162831-31-4
Pack Size Availability Price/USD Quantity
2 mg In stock $ 32.00
5 mg In stock $ 48.00
10 mg In stock $ 74.00
25 mg In stock $ 163.00
50 mg In stock $ 266.00
100 mg In stock $ 395.00
1 mL * 10 mM (in DMSO) In stock $ 93.00
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Purity: 99.72%
Purity: 99.71%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
Targets&IC50 GluR1:6 μM
In vitro IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. [1] IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization. [2]
Synonyms IEM 1754 dihydrobromide
Molecular Weight 412.25
Formula C16H30N2·2HBr
CAS No. 162831-31-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 75 mg/mL (181.9 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 76 mg/mL (184.4 mM)

TargetMolReferences and Literature

1. Magazanik LG, et al. J Physiol, 1997, 505( Pt 3), 655-663. 2. Tikhonov DB, et al. Br J Pharmacol, 2000, 129(2), 265-274.

Related compound libraries

This product is contained In the following compound libraries:
Neuronal Signaling Compound Library Bioactive Compounds Library Max Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library

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Keywords

IEM 1754 2HBr 162831-31-4 Neuroscience GluR AMPA receptor channel block IEM1754 IEM 1754 Ionotropic glutamate receptors voltage dependence IEM-1754 IEM1754 Dihydrobromide inhibit iGluR Inhibitor IEM 1754 dihydrobromide NMDA receptor IEM 1754 Dihydrobromide IEM-1754 Dihydrobromide inhibitor

 

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