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Gramine

Catalog No. T6519 CAS 87-52-5

Synonyms: NSC 16892, Donaxine

Gramine (Donaxine), a natural indole alkaloid, present in several plant species, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine has anti-tumor, anti-viral and anti-inflammatory properties.

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Gramine, CAS 87-52-5

Pack Size	Availability	Price/USD
25 mg	In stock	$ 38.00
50 mg	In stock	$ 55.00
100 mg	In stock	$ 79.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 98.44%

Purity: 97.23%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Gramine (Donaxine), a natural indole alkaloid, present in several plant species, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine has anti-tumor, anti-viral and anti-inflammatory properties.
Targets&IC50	AdipoR2:3.2 μM, AdipoR1:4.2 μM
Kinase Assay	Assay of protein kinase C: Protein kinase C is arrayed by measuring 32PI transferred from [gamma-32PI] ATP to lysine-rich histone type Ill-s. The reaction mixture (80 μL) contained 50 mM Tris-HCI. pH 7.4, 100 μM CaCl2, 10 mM MgCI2, 37.5 μL/mL histone type Ill-s, 10 μM [gamma-32PI] ATP (1250 cpm/pmol), 31 μM bovine brain phosphatidylserine and 0.5 μM 1,2 sn-dioleylglycerol. Fifteen μL of purified PKC (final concentration in assay 0.38 μg/mL) is added to the incubation mixture. After 10 min at 30°C, the reaction is stopped by addition of 30 μL of casein 30 mg/mL and 0.9 ml of 12% trichloroacetic acid. The acid precipitable material is collected by centrifugation, dissolved in 1N NaOH (100μL) and precipitated again with 1 ml of 12% trichloroacetic acid. The pellet is dissolved in 1N NaOH (100μL) and 32P incorporation is measured by scintillation counting in Aquasol.
Source	Natural Products > Poaceae > Arundo

Synonyms	NSC 16892, Donaxine
Molecular Weight	174.24
Formula	C11H14N2
CAS No.	87-52-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 33 mg/mL (189.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 33 mg/mL (189.4 mM)

References and Literature

1. Liu SL, Wang WW, Liu F, Li HY, Liu JS, Yang WD.Bull Environ Contam Toxicol. 2016 Apr;96(4):540-3. 2. Wei Y, Shi L, Wang K, Liu M, Yang Q, Yang Z, Ke S.Molecules. 2014 Jun 27;19(7):8949-64.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Active Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Compound Library Neurotransmitter Receptor Compound Library Traditional Chinese Medicine Monomer Library Immunology/Inflammation Compound Library Bioactive Compound Library Chinese Pharmacopoeia Natural Product Library Adrenergic Receptor-Targeted Compound Library

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Related compounds with same targets

Arctiin AdipoRon Ticlopidine

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Keywords

Gramine 87-52-5 GPCR/G Protein Microbiology/Virology Neuroscience Adrenergic Receptor Adiponectin receptor Reverse Transcriptase AdipoRs Inhibitor Adiponectin Receptor NSC-16892 NSC 16892 Beta Receptor inhibit Donaxine NSC16892 inhibitor

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