This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Girinimbine
Catalog No. TN6097 CAS
23095-44-5
Synonyms:
Girinimbin
Girinimbine (Girinimbin) is a carbazole alkaloid isolated from the plants M. koenigii, M. koenigii and Murraya koenigii.Girinimbine has a wide range of biological effects, including apoptosis, antitrypanosomal, antiplatelet, antimicrobial, anti-inflammatory, antioxidant and antitumor activities. Girinimbine has a variety of biological effects, including apoptosis, antitrypanosomal, antibacterial, anti-inflammatory, antioxidant and antitumor activities.
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Girinimbine (Girinimbin) is a carbazole alkaloid isolated from the plants M. koenigii, M. koenigii and Murraya koenigii.Girinimbine has a wide range of biological effects, including apoptosis, antitrypanosomal, antiplatelet, antimicrobial, anti-inflammatory, antioxidant and antitumor activities. Girinimbine has a variety of biological effects, including apoptosis, antitrypanosomal, antibacterial, anti-inflammatory, antioxidant and antitumor activities.
In vitro
Girinimbine (1-400 µM; 24-72 h; HepG2 cells) exhibits IC50 values of 61 µM, 56 µM, and 40 µM, reducing the viability of HepG2 cells at 24, 48, and 72 hours, respectively.[1] Girinimbine (10-100 µM; 24-48 h; HepG2 cells) increases LDH leakage in both concentration- and time-dependent manner in HepG2 cells.[1] Girinimbine (56 µM; 24-48 h; HepG2 cells) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells.[1] Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest.[1] Girinimbine exhibits a potent antitrypanosomal activity, with an IC50 value of 10.16 µg/mL.[3]
In vivo
Girinimbine (10-100 mg/kg; orally gavage; once; Male ICR mice) pretreatment effectively reduces total leukocyte migration and lowers pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid.[2] Girinimbine (20 μg/mL; 24 h; zebrafish embryos) shows a significant distribution of apoptotic cells in embryos.[2]
Synonyms
Girinimbin
Molecular Weight
263.33
Formula
C18H17NO
CAS No.
23095-44-5
Storage
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.