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Ganoderic acid H

Catalog No. TN1664 CAS 98665-19-1

Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-κB, resulting in the suppression of secretion of uPA.

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Ganoderic acid H, CAS 98665-19-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 283.00
5 mg	In stock	$ 853.00
10 mg	Inquiry	$ 1,150.00
50 mg	Inquiry	Inquiry

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Purity: 97.14%

Biological Description

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Description	Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-κB, resulting in the suppression of secretion of uPA.
In vitro	In highly invasive human breast cancer cells, Ganoderic acid H suppressed growth (cell proliferation and colony formation) and invasive behavior (adhesion, migration and invasion) of MDA-MB-231 cells[1]. Furthermore, the activity of Ganoderic acid H is linked to the hydroxylation in the positions 7 and 3 in its triterpene lanostane structure[1]. Ganoderic acid H could be a promising natural agent for the therapy of invasive breast cancers[1].
Source	Natural Products > Polyporaceae > Ganoderma

Molecular Weight	572.69
Formula	C32H44O9
CAS No.	98665-19-1

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (139.69 mM)

References and Literature

1. Jiang J, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. Int J Mol Med. 2008 May;21(5):577-84.

Related compound libraries

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Rare Natural Compound Library

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Keywords

Ganoderic acid H 98665-19-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair NF-Κb NF-κB CDK DNA/RNA Synthesis inhibit Inhibitor inhibitor

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