store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ganoderenic acid B, a natural product derived from Ganoderma lucidum, can work by inhibiting the transport function of ABCB1 and enhancing the cytotoxicity of chemotherapy drugs against AbCB1-mediated multidrug resistant cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 159.00 | |
5 mg | In stock | $ 396.00 | |
10 mg | In stock | $ 593.00 | |
25 mg | In stock | $ 929.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 490.00 |
Description | Ganoderenic acid B, a natural product derived from Ganoderma lucidum, can work by inhibiting the transport function of ABCB1 and enhancing the cytotoxicity of chemotherapy drugs against AbCB1-mediated multidrug resistant cancer cells. |
In vitro | Ganoderenic acid B, a lanostane-type triterpene isolated from Ganoderma lucidum, exhibited potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to doxorubicin, vincristine and paclitaxel. Similarly, Ganoderenic acid B could also significantly reverse the resistance of ABCB1-overexpressing MCF-7/ADR cells to doxorubicin. Furthermore, Ganoderenic acid B notably enhanced intracellular accumulation of rhodamine-123 in HepG2/ADM cells through inhibition of its efflux. ABCB1 siRNA interference assay indicated that the reversal activity of Ganoderenic acid B was dependent on ABCB1. Further mechanistic investigations found that Ganoderenic acid B did not alter the expression level of ABCB1 and the activity of ABCB1 ATPase. Molecular docking model displayed that the positions of Ganoderenic acid B binding to ABCB1 were different from the region of verapamil interacted with ABCB1. Ganoderenic acid B can enhance the cytotoxicity of chemotherapeutics towards ABCB1-mediated MDR cancer cells via inhibition of the transport function of ABCB1. These findings provide evidence that Ganoderenic acid B has the potential to be developed into an ABCB1-mediated multidrug resistance reversal agent.[1] |
Molecular Weight | 514.65 |
Formula | C30H42O7 |
CAS No. | 100665-41-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (174.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Ganoderenic acid B 100665-41-6 Membrane transporter/Ion channel Neuroscience P-gp inhibitor inhibit