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GSK1940029

Catalog No. T5427 CAS 1150701-66-8

Synonyms: SCD inhibitor 1

GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.

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GSK1940029, CAS 1150701-66-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.
In vitro	GSK1940029 is a stearoyl-coa desaturase (SCD) , methods of synthesis and uses ?in treating and/or preventing various diseases, including those mediated by SCD enzyme, such as diseases related to elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, skin disorders such as acne, diseases or conditions related to cancer.

Synonyms	SCD inhibitor 1
Molecular Weight	391.25
Formula	C18H16Cl2N4O2
CAS No.	1150701-66-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/mL (76.67 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Anne Marie Jeanne Bouillot, et al. 1, 2, 3-triazole derivatives for use as stearoyl-coa desaturase inhibitors . PCT Int. Appl. (2009), WO 2009060053 A1 20090514.

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK1940029 1150701-66-8 Metabolism Stearoyl-CoA Desaturase (SCD) Dehydrogenase Alzheimer's cancer SCD inhibitor-1 SCD inhibitor 1 cardiovascular,diabetes inhibit obesity SCD inhibitor1 metabolic GSK 1940029 elevated GSK-1940029 Inhibitor syndrome SCD enzyme inhibitor

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