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Furosemide

Catalog No. T0837 CAS 54-31-9

Synonyms: Lasix, Furosemid, Furanthril

Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.

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Furosemide, CAS 54-31-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.

In vitro

Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 dB, averaging 25-30 dB) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF. [1] Furosemide concentration- and time-dependently increases the formation of nitric oxide andprostacyclin. Furosemide leads to an enhanced release of kinins into the supernatant of the cells. [2] Furosemide reversibly suppresses low Ca2+-induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2+ model and the 4-aminopyridine model. [3] Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity. [4]

Synonyms	Lasix, Furosemid, Furanthril
Molecular Weight	330.74
Formula	C12H11ClN2O5S
CAS No.	54-31-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 33.1 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Charak BS, et al. J Antimicrob Chemother,1991, 27(1), 95-104. 2. Wiemer G, et al. J Pharmacol Exp Ther,1994, 271(3), 1611-1615. 3. Gutschmidt KU, et al. Neuroscience,1999, 91(4), 1471-1481. 4. Shiozaki A, et al. J Physiol Sci,2006, 56(6), 401-406. 5. Olsen SC, et al. Am J Vet Res, 1992, 53(5), 742-747.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Ion Channel Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library Kinase Inhibitor Library Approved Drug Library Anti-Cancer Drug Library

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Keywords

Furosemide 54-31-9 Neuroscience Membrane transporter/Ion channel GABA Receptor Na-K-Cl cotransporter NKCC edema hypertension inhibit Inhibitor Gamma-aminobutyric acid Receptor heart failure liver scarring Lasix γ-Aminobutyric acid Receptor Furosemid kidney disease Furanthril inhibitor

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