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Membrane transporter/Ion channel Na-K-Cl cotransporter Furosemide

Furosemide

Catalog No. T0837   CAS 54-31-9
Synonyms: Lasix, Furosemid, Furanthril

Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.

Furosemide, CAS 54-31-9
Pack Size Availability Price/USD Quantity
50 mg In stock 28.00
100 mg In stock 35.00
200 mg In stock 42.00
500 mg Inquiry 50.00
1 g Inquiry 59.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Purity 99.40%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.
Targets&IC50 Na-K-Cl cotransporter
In vitro Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 dB, averaging 25-30 dB) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF. [1] Furosemide concentration- and time-dependently increases the formation of nitric oxide andprostacyclin. Furosemide leads to an enhanced release of kinins into the supernatant of the cells. [2] Furosemide reversibly suppresses low Ca2+-induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2+ model and the 4-aminopyridine model. [3] Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity. [4]
Synonyms Lasix , Furosemid , Furanthril
Purity 99.40%
Molecular Weight 330.74
Formula C12H11ClN2O5S
CAS No. 54-31-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 33.1 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Charak BS, et al. J Antimicrob Chemother,1991, 27(1), 95-104. 2. Wiemer G, et al. J Pharmacol Exp Ther,1994, 271(3), 1611-1615. 3. Gutschmidt KU, et al. Neuroscience,1999, 91(4), 1471-1481. 4. Shiozaki A, et al. J Physiol Sci,2006, 56(6), 401-406. 5. Olsen SC, et al. Am J Vet Res, 1992, 53(5), 742-747.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Ion Channel Inhibitor Library FDA-approved Drug Library Kinase Inhibitor Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Cardiovascular Disease Compound Library Anti-cancer Drug library Drug Repurposing Library Target-Focused Phenotypic Screening Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library

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