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Flecainide acetate

Catalog No. T7219 CAS 54143-56-5

Synonyms: Flecainide (acetate), R-818

Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).

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Flecainide acetate, CAS 54143-56-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 48.00
25 mg	In stock	$ 87.00
50 mg	In stock	$ 140.00
100 mg	In stock	$ 189.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.91%

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Description	Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
In vivo	Flecainide (acetate) is an effective antiarrhythmic agent, free of side effects and when used orally is capable of terminating and controlling relatively resistant supraventricular tachycardia in children[1].
Animal Research	A total of 8 infants were treated with flecainide for refractory tachyarrhythmia's. Diagnosis on electrocardiogram (ECG) was atrioventricular reentry tachycardia (AVRT) in 5, atrial ectopic tachycardia (AET) in 2, a combination of AVRT and atrioventricular nodal reentry tachycardia (AVNRT) in 1. All patients had failed trial of antiarrhythmic drugs prior to presentation: digoxin and propranolol in 7, amiodarone in 3, cardioversion in 1. Flecainide (80-130 mg/m(2) orally) resulted in termination of the tachycardia in all 8 patients. Acute pharmacological termination of arrhythmia occurred with oral flecainide loading in 1 and temporarily with intravenous esmolol loading in 1 patient. Adjuvant therapy in form of propranolol was used in 5 and digoxin in 2. There were no side effects noted. Four episodes of recurrence were noted in 3 patients over 2 years, all of which responded to dose increase. Mean follow up time is 24.75 months[1].

Synonyms	Flecainide (acetate), R-818
Molecular Weight	474.39
Formula	C19H24F6N2O5
CAS No.	54143-56-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (105.40 mM)

References and Literature

1. Kohli, Vikas. Oral flecainide is effective in management of refractory tachycardia in infants[J]. Indian Heart Journal, 2013, 65(2):168-171. 2. Jean-François Desaphy, Luca A D , Didonna M P , et al. Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block[J]. The Journal of Physiology, 2004, 554(Pt 2):321-334.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Approved Drug Library Ion Channel Inhibitor Library

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Keywords

Flecainide acetate 54143-56-5 Membrane transporter/Ion channel Sodium Channel inhibit Na channels Flecainide (acetate) Na+ channels R-818 R 818 R818 Inhibitor Flecainide Acetate Flecainide inhibitor

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