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Favipiravir

Favipiravir
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Purity:100%
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Favipiravir

Catalog No. T6833Cas No. 259793-96-9
Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
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Pack SizePriceAvailabilityQuantity
5 mg$41In Stock
10 mg$57In Stock
50 mg$82In Stock
100 mg$124In Stock
500 mg$315In Stock
1 mL x 10 mM (in DMSO)$45In Stock
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Product Introduction

Bioactivity
Description
Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
In vitro
Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. [1] In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. [2]
In vivo
In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]
Cell Research
The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).(Only for Reference)
AliasT-705, 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide
Chemical Properties
Molecular Weight157.1
FormulaC5H4FN3O2
Cas No.259793-96-9
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 12 mg/mL(76.4 mM)
H2O: 5 mg/mL (31.82 mM)
DMSO: 45 mg/mL (286.44 mM)
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM6.3654 mL31.8269 mL63.6537 mL318.2686 mL
5 mM1.2731 mL6.3654 mL12.7307 mL63.6537 mL
10 mM0.6365 mL3.1827 mL6.3654 mL31.8269 mL
20 mM0.3183 mL1.5913 mL3.1827 mL15.9134 mL
DMSO
1mg5mg10mg50mg
50 mM0.1273 mL0.6365 mL1.2731 mL6.3654 mL
100 mM0.0637 mL0.3183 mL0.6365 mL3.1827 mL

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