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Etomoxir sodium salt

Catalog No. T4535 CAS 828934-41-4

Synonyms: (R)-Etomoxir sodium salt, Na salt, Etomoxir

Etomoxir sodium salt ((R)-Etomoxir sodium salt) is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that blocks fatty acid synthesis. Etomoxir sodium salt has antitumor activity.

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Etomoxir sodium salt, CAS 828934-41-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 155.00
50 mg	In stock	$ 278.00
100 mg	In stock	$ 455.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.82%

Purity: 99.67%

Purity: 99.43%

Purity: 99.39%

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Storage & Solubility Information

Description	Etomoxir sodium salt ((R)-Etomoxir sodium salt) is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that blocks fatty acid synthesis. Etomoxir sodium salt has antitumor activity.
In vitro	METHODS: BCa cell lines UM-UC-3 and T24 were treated with Etomoxir sodium salt (20-200 μM) for 24-72 h. Cell viability was examined using MTT. RESULTS: Etomoxir inhibited the viability of UM-UC-3 and T24 cells in a dose-dependent manner. [1] METHODS: Human breast cancer cells MCF-7 and T47D were treated with Etomoxir sodium salt (0.1-50 μM) for 24 h. Cellular FAO activity was measured by 3H palmitic acid. RESULTS: Low micromolar concentrations of Etomoxir were sufficient to achieve maximal inhibition of FAO in MCF-7 and T47D cells. [2]
In vivo	METHODS: To test the antitumor activity in vivo, Etomoxir sodium salt (40 mg/kg) was intraperitoneally injected into BALB/c nude mice carrying human bladder cancer tumor T24 every two days for twenty days. RESULTS: Etomoxir significantly inhibited tumor growth. [1] METHODS: To test the activity against multiple sclerosis, Etomoxir sodium salt (15 mg/kg) was intraperitoneally injected into a C57BL/6J mouse model of EAE induction once a week or every two days for two weeks. RESULTS: Etomoxir-treated mice showed reduced disease severity as well as reduced inflammation and demyelination. Disruption of fatty acid metabolism promotes downregulation of CNS inflammation and this metabolic pathway is a potential therapeutic target for multiple sclerosis. [3]

Synonyms	(R)-Etomoxir sodium salt, Na salt, Etomoxir
Molecular Weight	320.74
Formula	C15H18ClO4.Na
CAS No.	828934-41-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 199.5 mM

H2O: 5 mg/mL (15.59 mM), Sonication is recommended.

References and Literature

1. Cheng S, et al. Fatty acid oxidation inhibitor etomoxir suppresses tumor progression and induces cell cycle arrest via PPARγ-mediated pathway in bladder cancer. Clin Sci (Lond). 2019 Aug 7;133(15):1745-1758. 2. Ma Y, et al. Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation. Sci Rep. 2020 Jan 29;10(1):1450. 3. Shriver LP,et al. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Sci Rep. 2011;1:79. 4. Luiken JJ, et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. Biochem J. 2009 Apr 15;419(2):447-55.

Citations

1. Huang D, Chowdhury S, Wang H, et al. Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer. Cell Reports Medicine. 2021, 2(12): 100471. 2. Li M, Yang J, Ye C, et al. Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection. Virologica Sinica. 2021: 1-12.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Highly Selective Inhibitor Library Bioactive Compound Library Apoptosis Compound Library Human Metabolite Library Anti-COVID-19 Compound Library Anti-Metabolism Disease Compound Library Clinical Compound Library Bioactive Compounds Library Max

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Keywords

Etomoxir sodium salt 828934-41-4 Apoptosis Others inhibit Inhibitor Na FAO fatty β-oxidation palmitate acid (R)-Etomoxir sodium salt irreversible palmitoyltransferase oxidation Etomoxir sodium carnitine Na salt CPT-1a Etomoxir inhibitor

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