Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 188.00 | |
5 mg | In stock | $ 568.00 | |
10 mg | In stock | $ 752.00 | |
25 mg | In stock | $ 1,160.00 | |
50 mg | In stock | $ 1,570.00 | |
100 mg | In stock | $ 2,110.00 | |
500 mg | In stock | $ 4,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 466.00 |
Description | Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities. |
In vitro |
Molecular studies showed that 6,7,4'-THIF significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that 6,7,4'-THIF significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice.? |
In vivo |
A single administration of 6,7,4'-THIF significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests.?Moreover, treatment with 6,7,4'-THIF alone enhanced learning and memory performance in the same behavioral tests. 6,7,4'-THIF improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice |
Source |
Synonyms | 6,7,4'-Trihydroxyisoflavone |
Molecular Weight | 270.24 |
Formula | C15H10O5 |
CAS No. | 17817-31-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (462.55 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Desmethylglycitein 17817-31-1 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling PI3K/Akt/mTOR signaling PKC PI3K CDK Inhibitor 4',6,7-Trihydroxyisoflavone Phosphoinositide 3-kinase Cyclin dependent kinase inhibit 6,7,4'-Trihydroxyisoflavone Protein kinase C inhibitor