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DL-Laudanosine

Catalog No. T8175 CAS 1699-51-0

Synonyms: Laudanosine

DL-Laudanosine (Laudanosine) is a recognized metabolite of atracurium and cisatracurium.

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DL-Laudanosine, CAS 1699-51-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 42.00
10 mg	In stock	$ 59.00
25 mg	In stock	$ 93.00
50 mg	In stock	$ 135.00
100 mg	In stock	$ 197.00
1 mL * 10 mM (in DMSO)	In stock	$ 55.00

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Purity: 99.79%

Purity: 98.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

DL-Laudanosine (Laudanosine) is a recognized metabolite of atracurium and cisatracurium.

In vivo

laudanosine, a metabolite of atracurium and a central nervous system stimulant, might increase the minimum alveolar concentration (MAC) of halothane.?These estimates were used to determine the rates of infusion that would produce steady state plasma concentrations of laudanosine of approximately 200, 400, and 800 ng .?ml-1.?Subsequent infusion of laudanosine in eight rabbits produced mean (+/- SD) steady state plasma concentrations of laudanosine of 234 +/- 56, 457 +/- 66, and 873 +/- 105 ng .?ml-1.?The control value for MAC of halothane was 1.08 +/- 0.28%.?At the lowest steady state plasma laudanosine concentration, MAC did not significantly differ from control (MAC = 1.15 +/- 0.23%, P less than 0.1).?However, at 457 and 873 ng .?ml-1, laudanosine significantly increased the MAC of halothane by 23% and 30%, respectively.?Infusion with saline in two additional rabbits did not affect MAC. Therefore, at the plasma concentrations of laudanosine found in humans after administration of atracurium, laudanosine increased the MAC of halothane in rabbits[1].

Synonyms	Laudanosine
Molecular Weight	357.44
Formula	C21H27NO4
CAS No.	1699-51-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (30.77 mM)

References and Literature

1. Shi W Z , Fahey M R , Fisher D M , et al. Laudanosine (A Metabolite of Atracurium) Increases the Minimum Alveolar Concentration of Halothane in Rabbits[J]. Anesthesiology, 1985, 63(6):584-588. 2. Katz Y , Weizman A , Pick C G , et al. Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity[J]. brain research, 1994, 646(2):0-241.

Related compound libraries

This product is contained In the following compound libraries：

CNS-Penetrant Compound Library Natural Product Library Selected Plant-Sourced Compound Library NO PAINS Compound Library Natural Product Library for HTS Bioactive Compound Library RO5 Drug-like Natural Product Library Alkaloid Natural Product Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DL-Laudanosine 1699-51-0 Metabolism Others Drug Metabolite DLLaudanosine DL Laudanosine Inhibitor Laudanosine inhibit inhibitor

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