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D-ERYTHRO-SPHINGOSINE

Name: D-ERYTHRO-SPHINGOSINE
Brand: TargetMol
SKU: T5891
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5891Cas No. 123-78-4

Alias trans-4-Sphingenine, Sphingosine-1-phosphate, Sphingosine (d18:1), Sphinganine, Erythrosphingosine, erythro-C18-Sphingosine

D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator

D-ERYTHRO-SPHINGOSINE

🥰Excellent

Purity: 99.85%

Catalog No. T5891Alias trans-4-Sphingenine, Sphingosine-1-phosphate, Sphingosine (d18:1), Sphinganine, Erythrosphingosine, erythro-C18-SphingosineCas No. 123-78-4

D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator

Pack Size	Price	Availability
10 mg	$39	In Stock
25 mg	$64	In Stock
50 mg	$113	In Stock
100 mg	$172	In Stock
500 mg	$428	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Purity:99.85%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
Targets&IC50	p32:8 μM (EC50)
In vitro	D-erythro-Sphingosine inhibits protein kinase C in vitro[1]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[2].
Synonyms	trans-4-Sphingenine, Sphingosine-1-phosphate, Sphingosine (d18:1), Sphinganine, Erythrosphingosine, erythro-C18-Sphingosine

Chemical Properties

Molecular Weight	299.49
Formula	C₁₈H₃₇NO₂
Cas No.	123-78-4
Smiles	CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO
Relative Density.	0.939g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (834.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3390 mL	16.6950 mL	33.3901 mL	166.9505 mL
5 mM	0.6678 mL	3.3390 mL	6.6780 mL	33.3901 mL
10 mM	0.3339 mL	1.6695 mL	3.3390 mL	16.6950 mL
20 mM	0.1670 mL	0.8348 mL	1.6695 mL	8.3475 mL
50 mM	0.0668 mL	0.3339 mL	0.6678 mL	3.3390 mL
100 mM	0.0334 mL	0.1670 mL	0.3339 mL	1.6695 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc