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Clevidipine

Name: Clevidipine
Brand: TargetMol
SKU: T0999
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0999Cas No. 167221-71-8

Alias Cleviprex, Clevidipine butyrate

Clevidipine (Clevidipine butyrate) is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.

Clevidipine

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Purity: 99.40%

Catalog No. T0999Alias Cleviprex, Clevidipine butyrateCas No. 167221-71-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$53	In Stock	In Stock
50 mg	$81	In Stock	In Stock
100 mg	$133	In Stock	In Stock
200 mg	$240	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.40%

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Clevidipine AI Summary

Clevidipine demonstrates a high clearance rate (142.0 mL.min-1.kg-1) and a high level of plasma protein binding (fraction unbound, Fu = 0.0038), suggesting efficient elimination and strong plasma protein association. It has a short mean residence time (MRT = 0.07 hr), a fast half-life (T1/2 = 0.3 hr), and a moderate volume of distribution at steady state (Vdss = 0.58 L.kg-1). The compound effectively inhibits the L-type calcium channel in guinea pig ventricular myocytes with IC50 values of 7.1 nM and 78.8 nM. It also exhibits antiviral properties against the Ebola virus, with AC50 values ranging from 707.9 nM to 2.238 µM, and against SARS-CoV-2, demonstrated by various assays in different cell lines and conditions, showing inhibition percentages and hit scores indicating a potential for interfering with viral entry and replication mechanisms. Furthermore, Clevidipine inhibits human BSEP with an IC50 value of 36350.0 nM, indicating potential effects on bile salt transport. However, it exhibits no induction of drug-induced liver injury in human cells. It shows a low level of inhibition of cell viability in SARS-CoV-2 infected Vero E6 cells and moderate inhibition of SARS-CoV-2 3CL-Pro protease activity at 20 µM. Lastly, Clevidipine demonstrates inhibitory activity on the human HDAC6 enzyme, with 44.12% inhibition using a commercial peptide substrate and 0.64% with a custom peptide substrate, suggesting its potential bioactivity as an HDAC6 inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Clevidipine (Clevidipine butyrate) is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Targets&IC50	Short-acting dihydropyridine Ca2+ channel:7.1 nM
Synonyms	Cleviprex, Clevidipine butyrate

Chemical Properties

Molecular Weight	456.32
Formula	C₂₁H₂₃Cl₂NO₆
Cas No.	167221-71-8
Smiles	C(OCOC(CCC)=O)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=C(Cl)C(Cl)=CC=C2
Relative Density.	1.289g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 3 mg/mL (6.57 mM), Sonication is recommended.

DMSO: 84 mg/mL (184.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1914 mL	10.9572 mL	21.9144 mL	109.5722 mL
5 mM	0.4383 mL	2.1914 mL	4.3829 mL	21.9144 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2191 mL	1.0957 mL	2.1914 mL	10.9572 mL
20 mM	0.1096 mL	0.5479 mL	1.0957 mL	5.4786 mL
50 mM	0.0438 mL	0.2191 mL	0.4383 mL	2.1914 mL
100 mM	0.0219 mL	0.1096 mL	0.2191 mL	1.0957 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc