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cemadotin free base

Catalog No. T70407 CAS 159776-69-9

Synonyms: LU103793 free base

Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Cemadotin is used in research against cancer.

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cemadotin free base, CAS 159776-69-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 190.00
5 mg	In stock	$ 480.00
10 mg	In stock	$ 687.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,480.00

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Purity: 99.69%

ee: 100%

Purity: 99.44%

ee: 95.26%

Purity: 99.18%

Biological Description

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Storage & Solubility Information

Description	Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Cemadotin is used in research against cancer.
Targets&IC50	Tubulin:1 μM(Ki)
In vitro	Cemadotin (0-1 μM) significantly enhances the frequency of rescue while exerting minimal impact on the occurrence of catastrophes.[1] Cemadotin (0-100 μM ; 35 min) demonstrates a dose-dependent inhibition of polymerization in Tubulin-treated Strongylocentrotus purpuratus.[1] Cemadotin (0-1000 nM) selectively suppresses the rate and magnitude of tubulin growth excursions, with suppression correlating to drug concentration.[1] Cemadotin (400 pM~300 nM ; 72 h) inhibits the viability of HEK 293, F9, and HL60 cancer cells.[2]

Synonyms	LU103793 free base
Molecular Weight	640.86
Formula	C35H56N6O5
CAS No.	159776-69-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jordan MA, et al. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 ; 37(50):17571-17578. 2. Bernardes GJ, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed Engl. 2012 ; 51(4):941-944. 3. Supko JG, et al. A phase I clinical and pharmacokinetic study of the dolastatin analogue cemadotin administered as a 5-day continuous intravenous infusion. Cancer Chemother Pharmacol. 2000 ; 46(4):319-328.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library Anti-Cancer Compound Library

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Keywords

cemadotin free base 159776-69-9 Cytoskeletal Signaling Microtubule Associated LU-103793 cemadotin LU103793 free base LU 103793 LU103793 inhibitor inhibit

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