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T807

Catalog No. T19573   CAS 1415379-56-4
Synonyms: AV-1451

T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).

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T807 Chemical Structure
T807, CAS 1415379-56-4
Pack Size Availability Price/USD Quantity
2 mg In stock $ 39.00
5 mg In stock $ 64.00
10 mg In stock $ 109.00
25 mg In stock $ 196.00
50 mg In stock $ 339.00
100 mg In stock $ 578.00
200 mg In stock $ 798.00
500 mg In stock $ 1,220.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Purity: 98.83%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).
In vitro In vitro autoradiography results show that [18F]T807 exhibits strong binding to PHF-tau positive human brain sections with Kd of 14.6 nM. Comparison of autoradiography and double immunohistochemical staining of adjacent sections of PHF-tau and Ab showed that [18F] T807 binding is colocalized with immunoreactive PHF-tau pathology, but does not highlight Ab plaques[1]. [18F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [18F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified[2].
In vivo [18F]T807 can cross the blood-brain barrier and ished out quickly in mice models. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan[1].
Synonyms AV-1451
Molecular Weight 263.27
Formula C16H10FN3
CAS No. 1415379-56-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.6 mg/mL (63.05 mM)

TargetMolReferences and Literature

1. Xia CF, et al. [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimers Dement. 2013 Nov;9(6):666-76. 2. Marquié M, et al. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015 Nov;78(5):787-800.

Related compound libraries

This product is contained In the following compound libraries:
Microtubule-Targeted Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compounds Library Max Drug Repurposing Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Alzheimer's Disease Compound Library Anti-Neurodegenerative Disease Compound Library

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Keywords

T807 1415379-56-4 Cytoskeletal Signaling Microtubule Associated T-807 AV1451 T 807 Inhibitor AV-1451 inhibit AV 1451 inhibitor

 

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