Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 109.00 | |
25 mg | In stock | $ 196.00 | |
50 mg | In stock | $ 339.00 | |
100 mg | In stock | $ 578.00 | |
200 mg | In stock | $ 798.00 | |
500 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET). |
In vitro | In vitro autoradiography results show that [18F]T807 exhibits strong binding to PHF-tau positive human brain sections with Kd of 14.6 nM. Comparison of autoradiography and double immunohistochemical staining of adjacent sections of PHF-tau and Ab showed that [18F] T807 binding is colocalized with immunoreactive PHF-tau pathology, but does not highlight Ab plaques[1]. [18F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [18F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified[2]. |
In vivo | [18F]T807 can cross the blood-brain barrier and ished out quickly in mice models. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan[1]. |
Synonyms | AV-1451 |
Molecular Weight | 263.27 |
Formula | C16H10FN3 |
CAS No. | 1415379-56-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.6 mg/mL (63.05 mM)
You can also refer to dose conversion for different animals. More
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T807 1415379-56-4 Cytoskeletal Signaling Microtubule Associated T-807 AV1451 T 807 Inhibitor AV-1451 inhibit AV 1451 inhibitor