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Catalpol

Name: Catalpol
Brand: TargetMol
SKU: T2780
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2780Cas No. 2415-24-9

Alias Digitalis purpurea L, Catalpinoside

Catalpol (Catalpinoside) is an iridoid glycoside with neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.

Catalpol

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Purity: 99.89%

Catalog No. T2780Alias Digitalis purpurea L, CatalpinosideCas No. 2415-24-9

Catalpol (Catalpinoside) is an iridoid glycoside with neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$31	In Stock	In Stock
50 mg	$56	In Stock	In Stock
100 mg	$89	In Stock	In Stock
500 mg	$220	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Catalpol AI Summary

Catalpol exhibits a range of biological activities. It demonstrates antiproliferative effects against various human cell lines, including A2780, HBL100, HeLa, SW1573, T47D, and WiDr, with a GI50 value exceeding 100,000.0 nM for all tested lines based on the SRB assay results, suggesting limited cytotoxic effects at these concentrations. Additionally, it displays significant antihyperglycemic effects in streptozotocin-induced diabetic Wistar rats by reducing plasma glucose levels, with reductions of 24.33% at 0.1 mg/kg dosage and 8.53% at 0.01 mg/kg dosage. In terms of insecticidal activity, Catalpol is effective against Tribolium castaneum larvae, showing a pupal stage duration of 8.2 days and a mortality rate of 73.3% at 60 ug/uL. It also exhibits antifeedant activities such as a relative growth rate of -0.01 mg/mg/day and a relative consumption rate of 0.017 mg/mg/day at 200 ug/disk, along with an efficiency of conversion of ingested food of -66.1%. Catalpol inhibits Thermus aquaticus-DNA polymerase with an IC50 of 47800.0 nM and shows activity in a qHTS assay for GCN5L2 inhibitors with a potency of 39810.7 nM. It possesses estrogenic activity in human MVLN cells, with activity levels of 54.03% at 100 ug/mL and 75.78% at 20 ug/mL compared to estradiol. The compound shows moderate inhibitory activity against COX1 (44.2%-63.7%) and weak inhibitory action against COX2 (less than 30%). Additionally, Catalpol exhibits hepatoprotective activity against APAP-induced toxicity in human HepG2 cells, resulting in a 69.1% cell survival rate, and demonstrates inhibition of LPS-induced NO production in mouse BV2 cells with an IC50 of 7300.0 nM. It also shows cytotoxicity against mouse BV2 cells (86.1% activity) and various human cell lines (e.g., A2780, BGC823, HT-29, A549, and Bel7402) with IC50 values greater than 10,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Catalpol (Catalpinoside) is an iridoid glycoside with neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.
Synonyms	Digitalis purpurea L, Catalpinoside

Chemical Properties

Molecular Weight	362.33
Formula	C₁₅H₂₂O₁₀
Cas No.	2415-24-9
Smiles	OCC1OC(OC2OC=CC3C(O)C4OC4(CO)C23)C(O)C(O)C1O
Relative Density.	1.72 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (696.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7599 mL	13.7996 mL	27.5991 mL	137.9957 mL
5 mM	0.5520 mL	2.7599 mL	5.5198 mL	27.5991 mL
10 mM	0.2760 mL	1.3800 mL	2.7599 mL	13.7996 mL
20 mM	0.1380 mL	0.6900 mL	1.3800 mL	6.8998 mL
50 mM	0.0552 mL	0.2760 mL	0.5520 mL	2.7599 mL
100 mM	0.0276 mL	0.1380 mL	0.2760 mL	1.3800 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc