dhodh — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11027	DHODH-IN-4		Dehydrogenase
	DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, respectively. DHODH-IN-4 has antimalarial activity.		Dehydrogenase
T11019	DHODH-IN-1		Dehydrogenase
	DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.		Dehydrogenase
T11023	DHODH-IN-14		Dehydrogenase
	DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.		Dehydrogenase
T11022	DHODH-IN-13		Dehydrogenase
	DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.		Dehydrogenase
T11030	DHODH-IN-8		Dehydrogenase
	DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.		Dehydrogenase
T11024	DHODH-IN-15		Dehydrogenase
	DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis.		Dehydrogenase
T11021	DHODH-IN-12		Dehydrogenase
	DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.		Dehydrogenase
T40168	DHODH-IN-16		Dehydrogenase
	DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).		Dehydrogenase
T11020	DHODH-IN-11		Dehydrogenase , DNA/RNA Synthesis
	DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.		Dehydrogenase , DNA/RNA Synthesis
T67875	DHODH-IN-23		Dehydrogenase
	DHODH-IN-23 is a DHODH inhibitor with oral activity. DHODH-IN-23 is often used in cancer research.		Dehydrogenase
T60364	DHODH-IN-17		Dehydrogenase
	DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM. DHODH-IN-17 is a 2- anilino nicotinic acid that can be used in the study of acute myeloid leukemia (AML).		Dehydrogenase
T11031	HDHODH-IN-7	DHODH-IN-9	Dehydrogenase
	hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. hDHODH-IN-7 and pMIC50 of 7.4 have antiviral effects.		Dehydrogenase
T11028	HDHODH-IN-4	DHODH-IN-5	Dehydrogenase
	hDHODH-IN-4 (DHODH-IN-5) is a potent inhibitor of human dihydrogen dehydrogenase (DHODH). For human recombinant DHODH, its pIC50 is 7.8. hDHODH-IN-4 inhibits measles virus replication with a pMIC50 of 8.8.		Dehydrogenase
T11025	HDHODH-IN-3	DHODH-IN-2	Dehydrogenase
	hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.		Dehydrogenase
T11029	HDHODH-IN-5	DHODH-IN-7	Dehydrogenase
	hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).		Dehydrogenase
T40309	DHODH-IN-18
	DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).
T11026	DHODH-IN-3		Others
	DHODH-IN-3 is an effective inhibitor of human dihydroorotate dehydrogenase (HsDHODH) with IC50 value of 261 nM. DHODH-IN-3 binds to the ubiquinone binding cavity in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potenti...		Others
T63148	DHODH-IN-20
	Dhodh-in-20 (Compound 133) is a potent inhibitor of DHODH. Among them, DHODH is an iron-containing flavin-dependent enzyme that is present in the inner membrane of human mitochondria. DHODH-IN-20 showed an inhibitory eff...
T63652	DHODH-IN-19
	DHODH-IN-19 is a potent inhibitor of DHODH. DHODH-IN-19 has shown research potential for cancer and inflammatory diseases.
T63617	DHODH-IN-21
	DHODH-IN-21 is an orally active, selective dihydrolactate dehydrogenase (DHODH) inhibitor (IC50: 1.1 nM). DHODH-IN-21 exhibits anticancer effects and can be used to study acute myeloid leukemia (AML).