Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bicuculline ((+)-Bicuculline) is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
20 mg | In stock | $ 38.00 | |
50 mg | In stock | $ 63.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Bicuculline ((+)-Bicuculline) is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. |
Targets&IC50 | GABAA receptor:2 μM |
In vivo | (+)-Bicuculline, at concentrations of 1/3 μM, increased the EC50 of gamma-aminobutyric acid (GABA) by 1.6 times (41.0-67.0 μM) and by 3.6 times (36.1-129.0 μM), respectively. This compound also dose-dependently inhibited the Cl- conductance induced by GABA (40 μM) in the range of 1-100 μM. In addition, (+)-Bicuculline inhibited the agonistic effects of GABA (40 μM) on the α1β2γ2L receptor, functioning as an antagonist of the α1β2γ2L GABAA receptor. This action caused a parallel shift in the concentration-effect curve of GABA without affecting its maximum response. Furthermore, (+)-Bicuculline also exhibited inhibitory effects on Ca2+-activated potassium channels. |
Source |
Synonyms | (+)-Bicuculline, d-Bicuculline |
Molecular Weight | 367.35 |
Formula | C20H17NO6 |
CAS No. | 485-49-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36.7 mg/mL (100 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Bicuculline 485-49-4 Membrane transporter/Ion channel Neuroscience GABA Receptor convulsant inhibit alkaloid potassium γ-Aminobutyric acid Receptor AHP (+)-Bicuculline Gamma-aminobutyric acid Receptor d-Bicuculline competitive Inhibitor neurotransmitter inhibitor