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Barnidipine hydrochloride

Catalog No. T5856 CAS 104757-53-1

Synonyms: YM-09730-5 hydrochloride, Mepirodipine (hydrochloride)

Barnidipine hydrochloride (YM-09730-5 hydrochloride) is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery

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Barnidipine hydrochloride Chemical Structure

Barnidipine hydrochloride, CAS 104757-53-1

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 48.00
50 mg	In stock	$ 59.00
100 mg	In stock	$ 89.00
200 mg	In stock	$ 121.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Barnidipine hydrochloride (YM-09730-5 hydrochloride) is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery
Targets&IC50	[3H]-Initrendipine:0.21 nmol/l (Ki)
In vivo	Barnidipine demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day[1]. Formulations containing barnidipine have been used as a treatment for hypertension. In obstructive sleep apnea patients with non-dipper pattern hypertension, barnidipine reduced mean nighttime systolic and diastolic arterial blood pressure[2].
Animal Research	Forty-one patients (mean age 69 ± 17 years, 18 females) with previously diagnosed OSA (by reduced channel home-based polysomnography) who were not being treated with continuous positive airway pressure (CPAP) because of contraindications or because of patient intolerance or rejection were evaluated. Non-dipper status was defined as the presence of a nighttime fall in systolic blood pressure (BP) which was < 10% that of daytime systolic BP as observed in a previous ambulatory blood pressure (ABP) monitoring. OSA was defined according to the presence of 5 or more episodes per hour of apnoea, hypopnoea or arousal due to respiratory effort. The reproducibility of non-dipping status was confirmed through a second 24-h ABP monitoring performed at baseline. On top of the previous stable treatment regimen (which excluded calcium-channel blockers), a 10 mg dosing of barnidipine hydrochloride at bedtime was added to all subjects during a 12-week period[2].

Synonyms	YM-09730-5 hydrochloride, Mepirodipine (hydrochloride)
Molecular Weight	528
Formula	C27H30ClN3O6
CAS No.	104757-53-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (473.48 mM)

References and Literature

1. Kawashima K , Toda H , Oohata H , et al. Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive rats[J]. Gen Pharmacol, 1991, 22(2):263-266. 2. Giuseppe C , Luisa F M , Antonino C , et al. Effect of Bedtime Dosing of Barnidipine Hydrochloride in Nondipper Hypertensive Patients with Obstructive Sleep Apnoea not Treated with Continuous Positive Airway Pressure[J]. Journal of Clinical Hypertension, 2013, 15(2):339.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library Ion Channel Inhibitor Library Calcium Channel Compound Library NO PAINS Compound Library Anti-COVID-19 Compound Library

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Keywords

Barnidipine hydrochloride 104757-53-1 Membrane transporter/Ion channel Metabolism Calcium Channel Mepirodipine Ca2+ channels inhibit Barnidipine YM-09730-5 hydrochloride Inhibitor Ca channels Barnidipine Hydrochloride Mepirodipine (hydrochloride) YM-09730-5 Hydrochloride inhibitor

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