Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 175.00 | |
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 556.00 | |
25 mg | In stock | $ 896.00 | |
50 mg | In stock | $ 1,220.00 | |
100 mg | In stock | $ 1,650.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 397.00 |
Description | BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer. |
In vitro | BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 exhibts IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ~20 % max inhibition). |
In vivo | BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) shows dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses |
Synonyms | BMS986242 |
Molecular Weight | 410.91 |
Formula | C24H24ClFN2O |
CAS No. | 1923844-48-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (608.41 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BMS-986242 1923844-48-7 Metabolism Indoleamine 2,3-Dioxygenase (IDO) IDO glucuronidation potent cancer Inhibitor BMS 986242 inhibit BMS986242 active selective orally inhibitor