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Asperuloside

Catalog No. T3847 CAS 14259-45-1

Synonyms: Asperulosid

Asperuloside (Asperulosid) has anti-inflammatory activity.

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Asperuloside, CAS 14259-45-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 185.00
50 mg	In stock	$ 276.00

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Purity: 99.42%

Purity: 98.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Asperuloside (Asperulosid) has anti-inflammatory activity.
Kinase Assay	The chemiluminescent assay is used to confirm PCSEE MAO-A and MAO-B inhibitory effects and to test BNN and BVN hMAO-A and hMAO-B inhibition using MAO-Glo kit. Each enzyme's Arbitrary Light Unit (ALU) is measured in the presence of PCSEE, BNN, BVN, and standard DEP as an MAO-BI positive control. Briefly, hMAO-A and hMAO-B isozymes are diluted to 2× with reaction buffer (pH 7.4) and preincubated with 4× PCSEE, BNN, BVN, or DEP working solutions at RT for 30?min in white opaque 96-well plates. For determining activity inhibition, final 8.5?μg/mL concentrations of PCSEE, BNN, BVN, and DEP are used. For IC50 determination, 8× PCSEE and BNN working solutions are serially diluted using reaction buffers (pH 7.4) to make a 4× concentration. Ten points' range of PCSEE (1.0 to 250.0?μg/mL) and BNN (up to 400?μM (135.4?μg/mL)) final concentrations is used. Controls used are with and without ethanol. Ethanol solvent in controls is kept to a maximum final (volume) of ≤2%. Each isozyme is substituted with the reaction buffer for the blank. Based on our preliminary optimizations and Valley's method, the reaction is initiated by adding 4× luciferin derivative substrate (LDS) for a final (concentration) of 40 and 4?μM for hMAO-A and hMAO-B reactions, respectively. The final volume per well of each reaction is 50?μL. The reaction is optimized for the amount of A and B enzyme used to be incubated for less than 3.5?h at RT. To stop the reaction and produce the luminescence signal RLDR is added to all wells, 50?μL to each well, and incubated for a further 30?min.
Source	Natural Products > Rubiaceae > Galium

Synonyms	Asperulosid
Molecular Weight	414.36
Formula	C18H22O11
CAS No.	14259-45-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (144.8 mM)

References and Literature

1. Fujikawa T,et al. Asperuloside stimulates metabolic function in rats across several organs under high-fat diet conditions, acting like the major ingredient of Eucommia leaves with anti-obesity activity. J Nutr Sci. 2012 Sep 5;1:e10. 2. Venditti A,et al. Monoterpenoids glycosides content from two Mediterranean populations of Crucianella maritima L. Nat Prod Res. 2014;28(8):586-8.

Related compound libraries

This product is contained In the following compound libraries：

Miao medicine Compound Library Traditional Chinese Medicine Monomer Library Saccharide and Glycoside Natural Product Library Food as Medicine Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Selected Plant-Sourced Compound Library Covalent Natural Product Library

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Keywords

Asperuloside 14259-45-1 Immunology/Inflammation Others NO Synthase Inhibitor NOS Nitric oxide synthases Asperulosid inhibit inhibitor

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