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Articaine hydrochloride

Catalog No. T2131 CAS 23964-57-0

Synonyms: Ultracaine, Articaine HCl, Hoe-045

Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.

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Articaine hydrochloride Chemical Structure

Articaine hydrochloride, CAS 23964-57-0

Pack Size	Availability	Price/USD
25 mg	In stock	$ 38.00
50 mg	In stock	$ 54.00
100 mg	In stock	$ 91.00
200 mg	In stock	$ 141.00
500 mg	In stock	$ 233.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.88%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.

In vivo

The time to maximum drug concentrations of articaine occurs about 10 to 15 minutes after submucosal injection of articaine 4% 80 mg. The elimination half-time of articaine is about 20 minutes. Articaine is better able to diffuse through soft tissue and bone than other local anaesthetics, the concentration of articaine in the alveolus of a tooth in the upper jaw after extraction is about 100 times higher than that in systemic circulation. [1] Articaine: VAS (Visual Analogue Scale) scores (from 0 to 10 cm) by patients 4 to < 13 years of age are 0.5 for simple procedures and 1.1 for complex procedures, and average investigator scores are 0.4 and 0.6 for simple and complex procedures, respectively. No serious adverse events related to the articaine occurres, the only adverse event considered related to articaine is accidental lip injury in one patient. [2] Articaine results in success rate of 64.5% in electronic pulp testing in healthy adult volunteers injected with 4% articaine. Articaine infiltration produces significantly more episodes of no response to maximum stimulation in first molars than lidocaine. Mandibular buccal infiltration is more effective with 4% articaine with epinephrine compared to 2% lidocaine with epinephrine. [3] Articaine (4%) results in the success rate of 24% for the inferior alveolar nerve block in randomized, double-blind study. [4] Articaine formulation results in successful pulpal anesthesia ranged from 75 to 92 percent and onset of pulpal anesthesia ranged from 4.2 to 4.7 minutes in healthy volunteer. For articaine, 4 percent (two of 56) of the subjects reported swelling and no subjects reported bruising. Ninety-eight percent (59 of 60) of the subjects had lip numbness with the articaine solution. [5]

Synonyms	Ultracaine, Articaine HCl, Hoe-045
Molecular Weight	320.84
Formula	C13H21ClN2O3S
CAS No.	23964-57-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (187 mM)

H2O: 59 mg/mL (183.9 mM)

Ethanol: 60 mg/mL (187 mM)

References and Literature

1. Oertel R, et al. Clin Pharmacokinet, 1997, 33(6), 417-425. 2. Malamed SF, et al. Pediatr Dent, 2000, 22(4), 307-311. 3. Kanaa MD, et al. J Endod, 2006, 32(4), 296-298. 4. Claffey E, et al. J Endod, 2004, 30(8), 568-571. 5. Robertson D, et al. J Am Dent Assoc, 2007, 138(8), 1104-1112.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Approved Drug Library Bioactive Compound Library NO PAINS Compound Library Drug-Fragment Library Anti-Cardiovascular Disease Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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