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Amperozide

Catalog No. T23733 CAS 75558-90-6

Synonyms: FG 5606, Amperozida, Amperozidum

Amperozide (FG 5606) is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily around its capability for treating schizophrenia in humans.

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Amperozide, CAS 75558-90-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 148.00
5 mg	In stock	$ 336.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,520.00
1 mL * 10 mM (in DMSO)	In stock	$ 373.00

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Purity: 99.42%

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Description

In vitro

Amperozide inhibited the amphetamine-stimulated release of dopamine from perfused rat striatal tissue in a dose-dependent manner. With 1 and 10 microM amperozide there was significant inhibition of the amphetamine-stimulated release of dopamine, to 44 and 36% of control. In contrast, 10 microM amperozide significantly strengthened the electrically stimulated release of dopamine from perfused striatal slices. Amperozide 1-10 microM had no significant effect on the potassium-stimulated release of dopamine. 10 microM amperozide also slightly increased the basal release of 3H-dopamine from perfused striatal tissue[1].

Synonyms	FG 5606, Amperozida, Amperozidum
Molecular Weight	401.49
Formula	C23H29F2N3O
CAS No.	75558-90-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/ml (99.63 mM)

References and Literature

1. Gonyou HW, et al. Effects of amperozide and azaperone on aggression and productivity of growing-finishing pigs. J Anim Sci. 1988 Nov;66(11):2856-64. 2. Chang PY, et al. Behavioral and biochemical effects of amperozide and serotonin agents on nigrostriatal and mesolimbic dopamine systems. Chin J Physiol. 2008 Apr 30;51(2):106-15. Erratum in: Chin J Physiol. 2008 Jun 30;51(3):196. 3. Axelsson R, et al. Effects of amperozide in schizophrenia. An open study of a potent 5-HT2 receptor antagonist. Psychopharmacology (Berl). 1991;104(3):287-92. 4. Lankford MF, Myers RD. Opiate and 5-HT2A receptors in alcohol drinking: preference in HAD rats is inhibited by combination treatment with naltrexone and amperozide. Alcohol. 1996 Jan-Feb;13(1):53-7.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Inhibitor Library GPCR Compound Library Serotonin Receptor-Targeted Compound Library ReFRAME Related Library Anti-Cancer Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Human Metabolite Library

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Keywords

Amperozide 75558-90-6 GPCR/G Protein Neuroscience 5-HT Receptor FG 5606 FG-5606 FG5606 Amperozida Amperozidum inhibitor inhibit

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