Home Tools

Fluoxetine hydrochloride

Catalog No. T0450L CAS 56296-78-7

Synonyms: Fluoxetine HCl, LY-110140, Lilly110140

Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Fluoxetine hydrochloride Chemical Structure

Fluoxetine hydrochloride, CAS 56296-78-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 48.00
50 mg	In stock	$ 64.00
100 mg	In stock	$ 82.00
200 mg	In stock	$ 148.00
500 mg	In stock	$ 252.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

Bulk Inquiry

Select Batch

Purity: 99.66%

Purity: 99.6%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
In vitro	When co-administered in adult male SD rats, fluoxetine and olanzapine induce a robust and sustained increase in extracellular dopamine levels, with concentrations surpassing baseline by 361% and 272%, respectively—significantly higher than when either drug is used alone. Additionally, fluoxetine reverses the prolonged latency of escape caused by unavoidable shocks in adult male SD rats.
In vivo	Fluoxetine accelerates the maturation of immature neurons. It enhances the proliferation of new cells in the dentate gyrus of the adult rat hippocampus, strengthens neurodependent long-term potentiation in the hippocampal dentate gyrus, and increases the number of proliferating cells in the prefrontal cortex.

Synonyms	Fluoxetine HCl, LY-110140, Lilly110140
Molecular Weight	345.787
Formula	C17H19ClF3NO
CAS No.	56296-78-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 3.5 mg/mL (10 mM)

DMSO: 34.6 mg/mL (100 mM)

References and Literature

1. Malberg JE, et al. Neuropsychopharmacology, 2003, 28(9), 1562-1571. 2. Kodama M, et al. Biol Psychiatry, 2004, 56(8), 570-580. 3. Wang JW, et al. J Neurosci, 2008, 28(6), 1374-1384. 4. Bymaster FP, et al. Psychopharmacology (Berl), 2002, 160(4), 353-361. 5. Zhang W, et al. Neuropsychopharmacology, 2000, 23(3), 250-262. 6. Su WJ, et al. Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance. J Neuroinflammation. 2017 Oct 30;14(1):210. 7. Gao T T, Wang Y, Liu L, et al. LIMK1/2 in the mPFC plays a role in chronic stress-induced depressive-like effects in mice[J]. International Journal of Neuropsychopharmacology. 2020, 23(12): 821-836.

Citations

1. Gao T T, Wang Y, Liu L, et al. LIMK1/2 in the mPFC plays a role in chronic stress-induced depressive-like effects in mice. International Journal of Neuropsychopharmacology. 2020, 23(12): 821-836. 2. Zeng J, Xie Z, Chen L, et al.Rosmarinic acid alleviate CORT-induced depressive-like behavior by promoting neurogenesis and regulating BDNF/TrkB/PI3K signaling axis.Biomedicine & Pharmacotherapy.2024, 170: 115994.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library EMA Approved Drug Library Inhibitor Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Compound Library Anti-Parkinson's Disease Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

Prucalopride Succinate (4E)-SUN9221 Alprenolol hydrochloride Masupirdine free base Volinanserin Blonanserin PZ-1922 NLX-204 hydrochloride（2170405-10-2 free base）

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fluoxetine hydrochloride 56296-78-7 Autophagy GPCR/G Protein Neuroscience 5-HT Receptor Serotonin Transporter Fluoxetine HCl Fluoxetine SLC6A4 SERT inhibit Inhibitor LY 110140 5-HTT Fluoxetine Hydrochloride LY-110140 Lilly110140 LY110140 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.