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Alagebrium chloride

Catalog No. T7143 CAS 341028-37-3

Synonyms: ALT711

Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic

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Alagebrium chloride, CAS 341028-37-3

Pack Size	Availability	Price/USD	Quantity
200 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 100%

Purity: 98%

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Description	Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic
In vivo	Alagebrium treatment in diabetic rats significantly inhibits neointimal hyperplasia after carotid balloon injury due to its inhibition of intracellular ROS synthesis, which results in inhibition of RASMCs proliferation[1].
Animal Research	Rat aortic vascular smooth muscle cells (RASMCs) were treated with 1-100 μM of alagebrium added 24 hours before the addition of AGEs.?This in vivo study was done using 8-week-old male rats that were injected intraperitoneally with 80 mg/kg STZ.?Sixteen weeks later, the diabetic rats were treated with 10 mg/kg alagebrium for 4 weeks, after which carotid artery balloon injury was induced.?After 4 weeks, the animals were sacrificed for histological analysis[1].

Synonyms	ALT711
Molecular Weight	267.77
Formula	C13H14ClNOS
CAS No.	341028-37-3

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (93.36 mM)

References and Literature

1. Jin-Bae K , Byeong-Wook S , Sungha P , et al. Alagebrium Chloride, a Novel Advanced Glycation End-Product Cross Linkage Breaker, Inhibits Neointimal Proliferation in a Diabetic Rat Carotid Balloon Injury Model[J]. Korean Circulation Journal, 2010, 40(10):520-. 2. Watson A M D , Gray S P , Jiaze L , et al. Alagebrium Reduces Glomerular Fibrogenesis and Inflammation Beyond Preventing RAGE Activation in Diabetic Apolipoprotein E Knockout Mice[J]. Diabetes, 2012, 61(8):2105-2113.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Diabetic Compound Library NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Hypertension Compound Library ReFRAME Related Library Clinical Compound Library

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Related compounds with same targets

5α-Cholestan-3β-ol N-Acetyl-L-aspartic acid Tetrahydro-2H-pyran-2-one 2-Methoxybenzoic acid Pseudoginsenoside F11 [Leu5]-Enkephalin N8-Acetylspermidine dihydrochloride (±)-Leucine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Alagebrium chloride 341028-37-3 Metabolism Others Endogenous Metabolite ALT711 ALT-711 Inhibitor inhibit Alagebrium Alagebrium Chloride ALT 711 inhibitor

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