Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AG-270 is an allosteric and orally active inhibitor of MAT2A.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 112.00 | |
5 mg | In stock | $ 270.00 | |
10 mg | In stock | $ 432.00 | |
25 mg | In stock | $ 716.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,370.00 | |
500 mg | In stock | $ 2,730.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 297.00 |
Description | AG-270 is an allosteric and orally active inhibitor of MAT2A. |
Targets&IC50 | Mat2A:14 nM |
In vitro | AG-270 exhibits an IC50 of 20 nM in HCT116 MTAP-null cell SAM at 72 h[1].AG-270 demonstrates potent reduction in levels of intracellular SAM, as well as MTAP-null–selective antiproliferative activity in the HCT116 MTAP isogenic cell model in vitro[1]. |
Molecular Weight | 489.57 |
Formula | C30H27N5O2 |
CAS No. | 2201056-66-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (12.26 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AG-270 2201056-66-6 Chromatin/Epigenetic Others Methionine Adenosyltransferase (MAT) inhibit Inhibitor cancer Low AG270 AG 270 solid SAM pancreatic lymphoma tumor toxicity inhibitor