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2-hydroxy Flutamide

Catalog No. T7690 CAS 52806-53-8

2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer

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2-hydroxy Flutamide, CAS 52806-53-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 155.00
50 mg	In stock	$ 239.00
100 mg	In stock	$ 372.00
200 mg	In stock	$ 549.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer
In vitro	The pharmacologically active metabolite 2-hydroxy-flutamide, this principle metabolite increased CYP3A metabolism of midazolam in human microsomes (30%) and hepatocytes (110%)[1].

Molecular Weight	292.21
Formula	C11H11F3N2O4
CAS No.	52806-53-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25mg/ml(85.5 mM)

References and Literature

1. Blobaum A L , Byers F W , Bridges T M , et al. A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.[J]. Drug Metabolism & Disposition the Biological Fate of Chemicals, 2015, 43(11):1718. 2. Gao W , Kim J , Dalton J T . Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands[J]. Pharmaceutical Research, 2006, 23(8):1641-1658.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max Endocrinology-Hormone Compound Library Anti-Prostate Cancer Compound Library ReFRAME Related Library Clinical Compound Library

Related Products

Related compounds with same targets

Ganoderiol F Darolutamide AR antagonist 1 RU 58841 Androgen receptor degrader-2 Ailanthone S-23 Chlormadinone acetate

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Keywords

2-hydroxy Flutamide 52806-53-8 Endocrinology/Hormones Androgen Receptor Inhibitor inhibit prostate cancer HFT Flutamide 2 hydroxy Flutamide 2hydroxy Flutamide Hydroxyflutamide inhibitor

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