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Apoptosis BCL 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Catalog No. TN5263   CAS 569-83-5
Synonyms: Xanthohumol, Xanthohumol,

Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection.

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1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one, CAS 569-83-5
Pack Size Availability Price/USD Quantity
2 mg In stock 64.00
5 mg In stock 92.00
10 mg In stock 138.00
25 mg In stock 248.00
50 mg In stock 372.00
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Purity 99.79%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection.
Targets&IC50 AIF ,   Bcl-2 ,   Caspase ,   HCV ,   HIV ,   NMDAR ,   p53 ,   PARP ,   XIAP
In vitro Xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC50 values were 0.82, 1.28 and 0.50 microg/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC50 value of 20.74 microg/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by Xanthohumol[1].
In vivo Young and old mice were fed a diet supplemented with Xanthohumol for 8 weeks. Spatial memory was assessed with the Morris water maze and protein palmitoylation quantified. The young Xanthohumol-treated mice showed a significant improvement in cognitive flexibility. This evidence suggests that Xanthohumol may play a role in improving cognitive flexability in young animals, but it appears to be ineffective in adjusting the palmitoylation status of neuronal proteins in aged individuals[2].
Synonyms Xanthohumol , Xanthohumol ,
Purity 99.79%
Molecular Weight 354.4
Formula C21H22O5
CAS No. 569-83-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus. Antiviral Res. 2004 Dec;64(3):189-94. 1. Wang Q, et al. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus. Antiviral Res. 2004 Dec;64(3):189-94. 2. Zamzow D, et al. Xanthohumol improved cognitive flexibility in young mice. Behav Brain Res. 2014 Dec 15;275:1-10.

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