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(S)-Amisulpride

Catalog No. T26375 CAS 71675-92-8

Synonyms: Esamisulpride, (S) Amisulpride, SEP-4199

(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a Ki of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects.

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(S)-Amisulpride, CAS 71675-92-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 72.00
5 mg	In stock	$ 193.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 597.00
50 mg	In stock	$ 945.00
100 mg	In stock	$ 1,280.00
500 mg	In stock	$ 2,570.00
1 mL * 10 mM (in DMSO)	In stock	$ 213.00

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Purity: 98.16%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a Ki of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects.
Targets&IC50	5-HT7:900 nM(Ki)

Synonyms	Esamisulpride, (S) Amisulpride, SEP-4199
Molecular Weight	369.48
Formula	C17H27N3O4S
CAS No.	71675-92-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (270.65 mM), Sonication is recommended.

References and Literature

1. Timothy J Donahue, et al. (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics. Eur J Pharmacol. 2014 Jul 5;734:15-22. 2. Donahue TJ, Hillhouse TM, Webster KA, Young R, De Oliveira EO, Porter JH. Discriminative stimulus properties of the atypical antipsychotic amisulpride: comparison to its isomers and to other benzamide derivatives, antipsychotic, antidepressant, and antianxiety drugs in C57BL/6 mice. Psychopharmacology (Berl). 2017 Dec;234(23-24):3507-3520. doi: 10.1007/s00213-017-4738-y. Epub 2017 Sep 18. PubMed PMID: 28921163. 3. Liang Y, Yu X. Effectiveness of amisulpride in Chinese patients with predominantly negative symptoms of schizophrenia: a subanalysis of the ESCAPE study. Neuropsychiatr Dis Treat. 2017 Jun 28;13:1703-1712. doi: 10.2147/NDT.S140905. eCollection 2017. PubMed PMID: 28721051; PubMed Central PMCID: PMC5499925. 4. Graf H, Wiegers M, Metzger CD, Walter M, Grön G, Abler B. Noradrenergic modulation of neural erotic stimulus perception. Eur Neuropsychopharmacol. 2017 Sep;27(9):845-853. doi: 10.1016/j.euroneuro.2017.06.015. Epub 2017 Jul 3. PubMed PMID: 28683981.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Inhibitor Library Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library NO PAINS Compound Library Neuronal Signaling Compound Library Anti-Parkinson's Disease Compound Library Angiogenesis related Compound Library

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Keywords

(S)-Amisulpride 71675-92-8 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor Esamisulpride Inhibitor (R)-amisulpride antidepressant antipsychotic SEP 4199 Serotonin Receptor SEP4199 Amisulpride inhibit 5-hydroxytryptamine Receptor (S)Amisulpride (S) Amisulpride SEP-4199 inhibitor

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