Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 179.00 | |
5 mg | In stock | $ 450.00 | |
10 mg | In stock | $ 663.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,390.00 | |
100 mg | In stock | $ 1,880.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 432.00 |
Description | (R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor. |
Targets&IC50 | cdk2/cyclin A:0.072 μM, CDK5/p25:0.11 μM, CDK2/CyclinE:0.041 μM, CDK7/cyclin H:1.1 μM, CDK9/Cyclin T:0.18 μM, CK1δ/ε:0.4 μM, Cdk1/cyclin B:0.09 μM |
In vivo | A delayed systemic post-LFP administration at 3 hours of CR8--a potent second-generation cyclin-dependent kinase (CDK) inhibitor--reduced CCA;?cortical, hippocampal, and thalamic neuronal loss;?and cortical microglial and astrocyte activation.?Furthermore, CR8 treatment attenuated sensorimotor and cognitive deficits, alleviated depressive-like symptoms, and decreased lesion volume[1]. |
Synonyms | (R)-CR8, (R)-Isomer, CR8 |
Molecular Weight | 431.53 |
Formula | C24H29N7O |
CAS No. | 294646-77-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (25.49 mM)
You can also refer to dose conversion for different animals. More
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(R)-CR8 294646-77-8 Apoptosis Cell Cycle/Checkpoint CDK Inhibitor (R)CR8 caspases Cyclin dependent kinase CR-8 lesion (R)-CR8 death inhibit cell CR 8 (R)-CR-8 CR8, (R)-Isomer (R)?-?CR8 (R) CR8 Hippocampus neuroprotective (R)-Isomer CR8 Isomer PARP inhibitor