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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6894 ML264 1550008-55-3 98.72%
ML264
ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.
T7004 Tubercidin 69-33-0 98.66%
Tubercidin
Tubercidin (Sparsomycin A), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA repli...
T26674 AT-130 211364-06-6 98.62%
AT-130
AT-130 is a HBV virus inhibitor with improved potency (IC50 = 0.13 μM) and reduced toxicity in the HepAD38 cell line. AT-130 blocks HBV replication at the level ...
TNU0436 2-Thiocytidine 13239-97-9 98.59%
2-Thiocytidine
2-Thiocytidine is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and has a broad spectrum of antitumor activity.2-Thiocyt...
T1307 Carmofur 61422-45-5 98.59%
Carmofur
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencep...
T4060 Acelarin 840506-29-8 98.56%
Acelarin
Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.
TN1237 3-O-Methylgallic acid 3934-84-7 98.53%
3-O-Methylgallic acid
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may...
T0220 Foscarnet sodium 63585-09-1 98.52%
Foscarnet sodium
Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesv...
T3524 Halofuginone hydrobromide 64924-67-0 98.5%
Halofuginone hydrobromide
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
T2516 Amuvatinib 850879-09-3 98.48%
Amuvatinib
Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
T13166 TK216 1903783-48-1 98.45%
TK216
TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.
TQ0184 Chebulinic acid 18942-26-2 98.4%
Chebulinic acid
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T5363 Tempo 2564-83-2 98.35%
Tempo
Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a stru...
T60187 RP-6685 2832047-80-8 98.34%
RP-6685
RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGre...
T1465 Mupirocin 12650-69-0 98.33%
Mupirocin
Mupirocin (BRL-4910A) is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.
T9168 NSC 617145 203115-63-3 98.31%
NSC 617145
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manne...
TN1097 β-Boswellic acid 631-69-6 98.31%
β-Boswellic acid
β-Boswellic acid (Beta-boswellic acid) and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic acti...
T25466 GS-9191 859209-84-0 98.28%
GS-9191
GS-9191 is a potent inhibitor of DNA polymerase alpha and ß , a prodrug of the novel nucleoside analogue 9-(2-phosphonomethoxyethyl)guanine (PMEG) , which penetr...
T8842 IMT1B 2304621-06-3 98.26%
IMT1B
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing m...
T12935 SMN-C3 1449597-34-5 98.21%
SMN-C3
SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).
ML264
T6894
ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.
Tubercidin
T7004
Tubercidin (Sparsomycin A), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA repli...
AT-130
T26674
AT-130 is a HBV virus inhibitor with improved potency (IC50 = 0.13 μM) and reduced toxicity in the HepAD38 cell line. AT-130 blocks HBV replication at the level ...
2-Thiocytidine
TNU0436
2-Thiocytidine is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and has a broad spectrum of antitumor activity.2-Thiocyt...
Carmofur
T1307
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencep...
Acelarin
T4060
Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.
3-O-Methylgallic acid
TN1237
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may...
Foscarnet sodium
T0220
Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesv...
Halofuginone hydrobromide
T3524
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
Amuvatinib
T2516
Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
TK216
T13166
TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.
Chebulinic acid
TQ0184
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
Tempo
T5363
Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a stru...
RP-6685
T60187
RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGre...
Mupirocin
T1465
Mupirocin (BRL-4910A) is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.
NSC 617145
T9168
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manne...
β-Boswellic acid
TN1097
β-Boswellic acid (Beta-boswellic acid) and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic acti...
GS-9191
T25466
GS-9191 is a potent inhibitor of DNA polymerase alpha and ß , a prodrug of the novel nucleoside analogue 9-(2-phosphonomethoxyethyl)guanine (PMEG) , which penetr...
IMT1B
T8842
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing m...
SMN-C3
T12935
SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).
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TargetMol