Cysteine Protease

Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad.

Cat. No.	Product name	CAS No.	Purity
T6738	Z-FA-FMK	197855-65-5	99.43%
T6738	Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
T9710	Dazcapistat	2221010-42-8	99.41%
T9710	Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.
T12051	MIV-247	1352817-76-5	99.31%
T12051	MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuat...
T65868	Z-Lys-OH	2212-75-1	99.11%
T65868	Z-Lys-OH is a competitive inhibitor of papain, a lysine derivative.
T15303	FMK 9a	1955550-51-2	98.97%
T15303	FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.
TN1249	3-Epiursolic acid	989-30-0	98.81%
TN1249	3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an imp...
T27695	JTE-607	188791-09-5	98.72%
T27695	JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
T27730	KGP94	1131456-28-4	98.52%
T27730	KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).
T21616	L-006235	294623-49-7	98.38%
T21616	L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
T19384	Isovalerylcarnitine	31023-24-2	98.24%
T19384	Isovalerylcarnitine (3-methylbutyrylcarnitine) is a small molecule compound produced by the catabolism of L-leucine and the accumulation of isovaleric acid. Isov...
T20626	Esomeprazole	119141-88-7	98.20%
T20626	Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibit...
T12909	SID 26681509	958772-66-2	98.16%
T12909	SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
T60150	(1S,2R)-Alicapistat	2221010-57-5	98.05%
T60150	(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications...
T6564	Leupeptin Hemisulfate	103476-89-7	98.00%
T6564	Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the acti...
T6583	MG-101	110044-82-1	98%
T6583	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
T2493	PD 151746	179461-52-0	98%
T2493	PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0...
T3088	N-Ethylmaleimide	128-53-0	98%
T3088	N-Ethylmaleimide (NEM) is a sulfhydryl reagent that is widely used in experimental biochemical studies.
T7451	2-Cyanopyrimidine	14080-23-0	98%
T7451	2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)
TQ0116	LY 3000328	1373215-15-6	97.83%
TQ0116	LY 3000328 (Cathepsin S inhibitor) is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S).
T21509	CA 074	134448-10-5	97.80%
T21509	CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopat...