Powder: -20°C for 3 years
In solvent: -80°C for 6 months
LY 3000328 is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | 118.00 | |
5 mg | In stock | 221.00 | |
10 mg | In stock | 322.00 | |
25 mg | In stock | 570.00 | |
50 mg | In stock | 943.00 | |
100 mg | In stock | 1448.00 | |
1 mL * 10 mM (in DMSO) | In stock | 231.00 |
Description | LY 3000328 is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S). |
In vivo | The efficacies of LY3000328 is studied in a mouse model of abdominal aortic aneurysm (AAA). In this model, inflammation is induced using CaCl2 applied to the ablumenal surface. It is shown that the features of the disease state in this model resemble those of human AAA. LY3000328 (1, 3, 10, 30 mg/kg) exhibits a dose-responsive aortic diameter reduction. At the lowest dose of 1 mg/kg of LY3000328, the aortic diameter is reduced by 58%, then 83% at 3 mg/kg, and 87% at 10 mg/kg. The exposure (AUC) for both compounds increased in a dose-dependent manner, suggesting that the drug disposition properties of LY3000328 are favorable [1]. |
Synonyms | Cathepsin S inhibitor |
Purity | 99.01% |
Molecular Weight | 484.52 |
Formula | C25H29FN4O5 |
CAS No. | 1373215-15-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 6 months
DMSO: 48 mg/mL (99.06 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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