voltage-sensitive — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1198	Tetracaine hydrochloride	Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl	Calcium Channel , Sodium Channel
	Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been use...		Calcium Channel , Sodium Channel
T11979	McN5691	RWJ26240	Calcium Channel
	McN5691 is a voltage sensitive calcium channel blocker.		Calcium Channel
T18974	DiBAC4(3)		Others
	DiBAC4(3) is a voltage-sensitive fluorescent dye (λem=505 nm, λex=490 nm).		Others
T16448	PD173212		Calcium Channel
	PD 173212 is a blocker that blocks N-type voltage sensitive calcium channel (Cav2.2). PD173212 (0.0017-1.7 μmol/kg, Intraperitoneal Injection.) dose-dependently reduced DNBS-induced visceral hypersensitivity in mice.		Calcium Channel
T12015	Methyl homoveratrate		Others
	Methyl homoveratrate, a McN5691 (RWJ-26240) metabolite detected in vivo in plasma, urine, and fecal extracts, functions as a voltage-sensitive calcium channel blocker.		Others
T37688	Cyfluthrin		Reactive Oxygen Species , Sodium Channel
	Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests.		Reactive Oxygen Species , Sodium Channel
T23280	Ruthenium Red	Ammoniated ruthenium oxychloride	Calcium Channel
	Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids ...		Calcium Channel
T6474	Divalproex Sodium	Valproate semisodium,Epival	HDAC
	Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...		HDAC
T80458	ω-Conotoxin CVIA		Calcium Channel
	ω-Conotoxin CVIA, a 27-amino acid neuropeptide, functions as a blocker of voltage-sensitive calcium channels (VSCCs) [1].		Calcium Channel
T10609	Brevetoxin-3	PbTx-3	Others
	Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels.		Others
T18973	Di-8-ANEPPS		Others
	Di-8-ANEPPS, a voltage-sensitive dye, demonstrates shifts in both its fluorescence excitation and emission spectra in response to changes in membrane potential (Vm).		Others
T30078	ANNINE-6plus
	ANNINE-6plus is a water soluble voltage sensitive dye (also called potentiometric dyes). This compound was developed at the Max Planck Institute for Biochemistry in Germany. It is used to optically measure the changes in...
T28227	Oe-9000	Oe 9000
	Oe-9000 is a blocker of voltage-gated Na(+) currents in neurons. It reversibly reduces rapidly activating and inactivating TTX-sensitive (TTX-S) Na(+) currents as well as slowly activating and inactivating tetrodotoxin-r...
T80161	ω-Conotoxin SO3		Calcium Channel
	ω-Conotoxin SO3 is an analgesic peptide that functions as an antagonist to N-type voltage-sensitive calcium channels, and can be isolated from the venom of Conus striatus [1] [2].		Calcium Channel
T61145	Topiramate lithium
	Topiramate lithium (McN 4853) is a wide-ranging antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action involves enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltag...
T80851	VSTx-3	Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F
	VSTx-3 is a potassium voltage-gated channel (K_V) blocker, which has also been shown to be a potent tetrodotoxin-sensitive (TTX-sensitive) sodium channel inhibitor, with particular efficacy against NaV1.8 channels, as ev...
T80189	Hainantoxin-IV	HNTX-IV	Sodium Channel
	Hainantoxin-IV acts as a specific antagonist for tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with His28 and Lys32 being critical residues for binding to the target. This compound also features an inhibi...		Sodium Channel
TN4183	Hardwickiic acid	(-)-Hardwikiic acid	Sodium Channel
	Hardwickiic acid ((-)-Hardwikiic acid) is a natural compound derived from Pulicaria gnaphalodes and is an anti-injury receptor compound. hardwickiic acid blocks tetrodotoxin-sensitive voltage-dependent sodium channels. h...		Sodium Channel
T24692	QAQ dichloride
	QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit...
T80495	MHuwentoxin-IV		Sodium Channel
	mHuwentoxin-IV, a naturally modified form of Huwentoxin-IV, selectively inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels in dorsal root ganglion neurons with an IC50 value of 54.16 nM. Notably, the i...		Sodium Channel