Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 4-5 weeks | $ 1,270.00 |
Description | Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels. |
Targets&IC50 | Na+-ATPase: |
In vitro | Brevetoxin-3, at concentrations ranging from 30-500 nM, induces a shift in activation towards more negative membrane potentials, facilitating the observation of single-channel activity under steady-state conditions (specifically, maintained depolarization at -50 mV) [1]. |
In vivo | Brevetoxin-3 (intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh [3]. |
Synonyms | PbTx-3 |
Molecular Weight | 897.112 |
Formula | C50H72O14 |
CAS No. | 85079-48-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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