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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11469 | GSK-3484862 | DNA Methyltransferase | |
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer. | |||
T77614 | DpC | Others | |
DPC is an antitumor compound that inhibits cancer cell proliferation with an IC50 of 0.007-0.096 μM.DPC is involved in a variety of anticancer therapies and can be used in cancer research. | |||
T8839 | ICCB280 | Apoptosis , Others | |
ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavo... | |||
T9498 | BAY-8400 | DNA-PK | |
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in combination with targeted alpha therapies. BAY-8400 can be used for... | |||
T3625 | Bempedoic acid | ETC1002,ESP-55016,ETC 1002,ETC-1002 | ATP Citrate Lyase , AMPK |
Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic ... | |||
T3579 | PLX8394 | Raf | |
PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, then inhibit the prolif... | |||
T27497 | GSK-982 | GSK 982,GSK982 | |
GSK-982, an opioid receptor antagonist, has activity as potential therapies for obesity. | |||
T40166 | Bexirestrant | ||
Bexirestrant is an orally active ER-α degrader commonly employed in the research of antiestrogen and antineoplastic therapies. | |||
T30236L | Axelopran sulfate | ||
Axelopran sulfate is used in Oral Therapies for Opioid-induced Bowel Dysfunction in Patients with Chronic Noncancer Pain. | |||
T71245 | ARRY-502 | ||
ARRY-502 is a CRTH2 antagonist. Regulation of cytokine activity is important in molecularly targeted therapies for asthma. | |||
T71865 | DSM43 | ||
DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The p... | |||
T79340 | GLS1 Inhibitor-7 | Glutaminase | |
GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, and antiobesity therapies [1]. | |||
T69776 | BAY-707 acetate | ||
BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1. Despite superior cellular target engagement and pharmacokinetic properties, inhibition of MTH1 with BAY-707 resulted in a clear lack of i... | |||
T70847 | BMS-351 | ||
BMS-351 is a potent and selective, nonsteroidal CYP17A1 lyase inhibitor with robust selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 emerges as an outstanding preclinical candidate to treat CRPC and is likely t... | |||
T74337 | DNA crosslinker 1 dihydrochloride | ||
DNA Crosslinker 1 (dihydrochloride) serves as a potent binder for the DNA minor groove, exhibiting a DNA binding affinity (ΔTm) of 1.1°C. This compound is utilized in research focused on anticancer therapies [1]. | |||
T38910 | MGluR2 antagonist 1 | ||
mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, ... | |||
T79136 | DGKζ-IN-1 | ||
DGKζ-IN-1 (compound 9) is a DGKζ inhibitor with potential applications in cancer research, particularly for studying immunocyte activation and resistance to anti-PD-1/anti-PD-L1 antibody therapies [1]. | |||
T82046 | Irisquinone | ||
Irisquinone, a natural anticancer agent, also acts as a radiation sensitizer for cancer therapies. It diminishes glutathione (GSH) levels and hampers the repair of single-strand DNA breaks [1] [2] [3]. | |||
T82296 | GluN1(359-378) | ||
GluN1 (359-378) is an antibody targeting the N-methyl-D-aspartate receptor (NMDAR) capable of crossing the blood-brain barrier and is utilized in researching therapies for anti-NMDAR encephalitis that focus on the immune... | |||
T80578 | Evunzekibart | ATOR-1017 | |
Evunzekibart (ATOR-1017) is an Fc-γ receptor-dependent 4-1BB agonist and an IgG4 isotype antibody. It can function as a monotherapy or synergize with anti-PD1 therapies to promote anti-tumor effects. |