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Search Results for " spindles "

10

Compounds

Cat No. Product Name Synonyms Targets
T14965 Ciliobrevin D ATPase , Hedgehog/Smoothened
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity ...
T3118 Dimethylenastron Kinesin
Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
T15576 Indibulin ZIO 301,D 24851 Apoptosis , Microtubule Associated
Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu...
T0939 Phenytoin Diphenylhydantoin,5,5-Diphenylhydantoin Virus Protease , Sodium Channel
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor...
T75576 Solidagonic acid
Solidagonic acid, by inhibiting HSET motor activity, promotes the conversion of abnormal monopolar spindles to bipolar configurations, effectively suppressing fission yeast cell death and facilitating the mitotic spindle...
T37063 Laulimalide
Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, pre...
T68686 DAP-81
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50...
T68743 AZD4877 HCl
AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may re...
T68480 4SC-207
4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell ...
T70527 DAT-230
DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -tr...
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