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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12885 | SGC-AAK1-1 | AAK1 (AP2 associated kinase 1) | |
SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe. | |||
T6668 | SGC-CBP30 | Epigenetic Reader Domain , Histone Acetyltransferase | |
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM). | |||
T9568 | SGC-SMARCA-BRDVIII | Epigenetic Reader Domain | |
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively. | |||
T5169 | SGC-GAK-1 | Serine/threonin kinase | |
SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM). | |||
T40131 | SGC-CK2-1 | SGC-CK2-1 | |
SGC-CK2-1 is an ATP-competitive chemical compound that acts as a highly potent and cell-active CK2 inhibitor. It demonstrates excellent selectivity towards both isoforms of human CK2, with IC50 values of 36 nM for CK2α a... | |||
T34630 | SGC-AAK1-1N | SGCAAK11N,SGCAAK1-1N,SGC-AAK11N | |
SGC-AAK1-1N is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) with an IC 50 of 1.8 μM [1]. | |||
T34631 | SGC-GAK-1N | SGC-GAK1N,SGCGAK1N,SGCGAK-1N | |
SGC-GAK-1N is a negative control for SGC-GAK-1. | |||
T36976 | SGC 6870 | ||
Potent and selective protein arginine methyltransferase 6 (PRMT6) inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric ... | |||
T37467 | SGC 6870N | ||
Negative control for SGC 6870 (Cat. No. 7182). SGC 6870N is the (S)-enantiomer, which is inactive on PRMT6. | |||
T12886 | SGC-iMLLT | Histone Methyltransferase | |
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM). | |||
T69551 | SGC-STK17B-1 | ||
SGC-STK17B-1 is a potent and selective inhibitor of STK17B/DRAK2 kinase. | |||
T34629 | SGC3027N | SGC-3027N,SGC 3027N | |
SGC3027N is a negative control for SGC3027 (GLXC-12451). | |||
T3084 | SGC707 | Histone Methyltransferase | |
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3. | |||
T7089 | SGC2085 | Histone Methyltransferase | |
SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM). | |||
T79542 | SGC-UBD253 | HDAC | |
SGC-UBD253 is a potent antagonist of the HDAC6-UBD interaction and may be utilized in cancer research [1]. | |||
T62471 | SGC agonist 1 | ||
SGC agonist 1 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 1 is able to increase solubility and has high cell permeability. | |||
T62909 | SGC agonist 2 | ||
SGC agonist 2 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 2 has potential for cardiovascular disease (heart failure, angina, pulmonary hypertension, myocardial infarction) and fibrotic disease (renal... | |||
T3082 | SGC0946 | Histone Methyltransferase | |
SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells. | |||
T4013 | SGC2085 HCl | Histone Methyltransferase | |
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulat... | |||
T69580 | SGC6870 | ||
SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases. |