phosphodiesterase-4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36018	Phosphodiesterase 4 Inhibitor
	Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 μM for the human recombinant enzyme.
T27172	Difamilast		PDE
	Difamilast is an inhibitor of phosphodiesterase IV.		PDE
T7954	YM976		PDE
	YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)		PDE
TN2159	Robustine		PDE
	Robustine is a natural product, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro.		PDE
T2923	Apremilast	CC-10004	Apoptosis , TNF , PDE
	Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.		Apoptosis , TNF , PDE
T16164	MY-5445	N-(3-chlorophenyl)-4-phenylphthalazin-1-amine	PDE
	MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).		PDE
T4S0792	Pinoresinol 4-O-β-D-glucopyranoside	(+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside	Others
	(+)-Pinoresinol-β-D-glucoside, also known as (+)-pinor, is a major active lignan furanoid found in Forsythia. It exhibits antioxidative, antihypertensive activities, and acts as an inhibitor of cyclic adenosine monophosp...		Others
T17199	Udenafil		PDE
	Udenafil is an inhibitor of PDE5 .		PDE
T19706	Ro 20-1724	Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724	PDE
	Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.		PDE
T4695	CP671305		PDE
	CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.		PDE
T33422	MK-0873	MK 0873,MK0873	PDE
	MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.		PDE
T19865	GEBR-7b	3-(Cyclopentyloxy)-4-methoxybenzaldehyde	PDE
	GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.		PDE
T4285	Crisaborole	AN-2728,PF-06930164	PDE
	Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.		PDE
T3987	Lotamilast	E6005,RVT-501	PDE
	Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.		PDE
T30232	AWD 12-281	GSK 842470,GSK-842470,AWD12-281,AWD-12-281,GW 842470	PDE
	AWD 12-281 is a selective phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory and bronchodilator activity used in the study of chronic obstructive pulmonary disease (COPD).		PDE
T27475	GSK356278	GSK-356278,GSK 356278	PDE
	GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognitio...		PDE
T6644	Rolipram	SB 95952,ZK 62711,(R,S)-Rolipram	HIV Protease , Antibacterial , PDE
	Rolipram (SB 95952) is a phosphodiesterase 4 inhibitor with antidepressant properties.		HIV Protease , Antibacterial , PDE
T12103	MR-L2		PDE
	MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).		PDE
T23256	RS-25344 hydrochloride		PDE
	RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor		PDE
T9239	RS-25344		PDE
	RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.		PDE