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MK-0873

Catalog No. T33422 CAS 500355-52-2

Synonyms: MK 0873, MK0873

MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MK-0873, CAS 500355-52-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 146.00
5 mg	In stock	$ 350.00
10 mg	In stock	$ 530.00
25 mg	In stock	$ 859.00
50 mg	In stock	$ 1,180.00
100 mg	In stock	$ 1,590.00
500 mg	In stock	$ 3,190.00

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Purity: 99.29%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.

In vitro

Eight healthy, non-smoking male subjects participated in this randomized, open-label, 2-period, cross-over study. In one period subjects received an oral dose of 2.5mg MK-0873 for 6 days co-administered with a single oral dose of 250 mg theophylline on day 5. The other period consisted of a single dose of 250 mg of theophylline on day 1. In each period, blood samples were collected at predefined time points. In this study, in a limited number of subjects, co-administration of oral MK-0873 did not affect the pharmacokinetics, safety, and tolerability of oral theophylline in non-smoking healthy male subjects.[3]

Synonyms	MK 0873, MK0873
Molecular Weight	422.44
Formula	C25H18N4O3
CAS No.	500355-52-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1mg/ml, Sonication is recommended.

References and Literature

1. Mitra A, et al. Use of minipig skin biopsy model as an innovative tool to design topical formulation to achieve desired pharmacokinetics in humans. J Pharm Sci. 2015 May;104(5):1701-8. 2. Guay D, et al. Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5554-8. 3. Boot JD, et al. MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers. Pulm Pharmacol Ther. 2008;21(3):573-7.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Clinical Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MK-0873 500355-52-2 Metabolism PDE MK 0873 MK0873 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.