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YM976
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Catalog No. T7954Cas No. 191219-80-4
YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)
YM976
Copy Product Info🥰Excellent
Purity: 99.84%
Catalog No. T7954Cas No. 191219-80-4
YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $42 | In Stock | In Stock | |
| 25 mg | Preferential | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $32 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.84%
Appearance:Solid
Color:White
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Product Introduction
YM976 AI Summary
YM976 demonstrates diverse bioactivities across various biological targets and mechanisms. It acts as a potent inhibitor for enzymes such as HSD17B4, JMJD2E, ALDH1A1, Cytochrome P450 3A4, Cytochrome P450 2C9, and T. brucei phosphofructokinase, as well as for pathways including Anthrax Lethal Toxin Internalization, ROR gamma transcriptional activity, Lassa Virus entry into cells, and USP1/UAF1 complex. Additionally, it serves as an agonist for the Thyroid Stimulating Hormone Receptor and modulates lipid storage. It also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) and G Protein Signaling RGS4 and acts as a substrate for Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1). Moreover, YM976 enhances Arylsulfatase A (ASA1) activity in the LOPAC Validation Assay and induces the Endoplasmic Reticulum Stress Response (ERSR) in human glioma cells.
Specifically, YM976 exhibits antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity. It reduces cytotoxicity in Caco-2 cells by 6.16% at a concentration of 10 µM after 48 hours and shows an inhibition rate of 0.53% in VERO-6 cells under similar conditions. However, it appears to have a complex interaction with SARS-CoV-2 3CL-Pro protease, showing a negative inhibition percentage of -2.058% at 20 µM. Additionally, YM976 inhibits human HDAC6, with a slightly higher inhibition rate when using a commercial peptide substrate (17.75%) compared to a custom peptide substrate (-4.64%). Thus, YM976 holds potential as a multi-target therapeutic agent with antiviral and enzymatic regulatory activities..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM) |
| Targets&IC50 | PDE4:2.2 nM |
| Molecular Weight | 313.78 |
| Formula | C17H16ClN3O |
| Cas No. | 191219-80-4 |
| Smiles | CCc1ccc2c(nc(=O)n(CC)c2n1)-c1cccc(Cl)c1 |
| Relative Density. | 1.27g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.14 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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