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YM976

Catalog No. T7954 CAS 191219-80-4

YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)

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YM976, CAS 191219-80-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 70.00
25 mg	In stock	$ 116.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)
Targets&IC50	PDE4:2.2 nM

Molecular Weight	313.78
Formula	C17H16ClN3O
CAS No.	191219-80-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.14 mg/mL (10 mM)

References and Literature

1. Aoki M , Kobayashi M , Ishikawa J , et al. A Novel Phosphodiesterase Type 4 Inhibitor, YM976 (4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with Little Emetogenic Activity[J]. Journal of Pharmacology & Experimental Therapeutics, 2000, 295(1):255-260. 2. Aoki M , Yamamoto S , Kobayashi M , et al. Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1):165-173.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Metabolism Compound Library Anti-Alzheimer's Disease Compound Library Bioactive Compounds Library Max Anti-Cardiovascular Disease Compound Library Bioactive Compound Library NO PAINS Compound Library Anti-Metabolism Disease Compound Library ReFRAME Related Library

Related Products

Related compounds with same targets

Vardenafil dihydrochloride PF-00489791 Rolipram OPC18750 HCl Bucladesine sodium MBCQ Zaprinast Cilostazol

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

YM976 191219-80-4 Metabolism PDE Phosphodiesterase (PDE) PDE4 inhibitor inhibit phosphodiesterase 4 anti-inflammatory activities antigen-induced airway responses Inhibitor YM 976 YM-976 inhibitor

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