ob/ob — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T41175	OB 24 hydrochloride
	OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in adv...
T28224	OB-2
	OB-2 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-2 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo.
T68288	OB-24 free base
	OB-24 free base is a potent and selective heme oxygenase 1 (HO-1) inhibitor.
T28223	OB-1
	OB-1 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-1 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo.
T9266	Fatostatin		Lipid , Fatty Acid Synthase
	Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.		Lipid , Fatty Acid Synthase
T6832	Fatostatin hydrobromide	Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1 , Fatty Acid Synthase
	Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.		NPC1L1 , Fatty Acid Synthase
T71294	BMS-763534
	BMS-763534 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).
T31752	FD&C Yellow No. 4	NSC-11234,NSC11234,Yellow OB,NSC 11234
	FD&C Yellow No. 4 is a dye.
T3312	AM-2394	AM2394	Glucokinase
	AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel...		Glucokinase
T23557	Talibegron hydrochloride	ZD2079 hydrochloride,ZD 2079	Adrenergic Receptor
	Talibegron hydrochloride (ZD2079 hydrochloride) is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. In...		Adrenergic Receptor
T70509	INU-101
	INU-101 is an 11β-HSD1 inhibitor. In KKAy mice, ob/ob mice, and ZDF rats, oral administration of INU-101 led to enhanced insulin sensitivity and the lowering of the fasting level of glucose in the blood. INU-101 therefor...
T27239	Edaglitazone	Edaglitazone sodium,BM-13.1258,RO-2052349-602,R-483,RO-2052349-000
	Edaglitazone is a PPARγ agonist. Edarglitazone restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse.
TP2020	[Pro3]-GIP (Mouse)
	GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intra...
T83696	Gastric Inhibitory Peptide 1 (3-42) (human) TFA	Glucose-dependent Insulinotropic Polypeptide 3-42,GIP-1 (3-42)
	Gastric inhibitory peptide 1 (GIP-1) (3-42), a fragment of the incretin hormone GIP and antagonist to the GIP receptor, is generated through the action of serum dipeptidyl peptidase 4 (DDP-4). When administered at 25 nmo...
T71296	4-Aaqb
	4-Aaqb, also known as OB-318, is a natural inhibitor of the autophagy pathway, enhancing immune function, suppressing MAPK and NFκB, showing anti-inflammatory, hypoglycemic, vasorelaxative, and antiproliferative activiti...
TP1356	Leptin (22-56), human
	Leptin(22-56),human is a peptide fragment of Leptin, which ACTS through a variety of subtypes of Ob-Rs.
T16507	PF-5006739		Casein Kinase
	PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency...		Casein Kinase
T69603	BR103354
	BR103354 is a novel fibroblast activation protein (FAP) inhibitor with anti-diabetic and anti-steatotic effects. BR103354 inhibited FAP with an IC50 value of 14 nM, showing high selectivity against dipeptidyl peptidase (...