mglur3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9970	mGluR3 modulator-1	1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile	GluR
	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.		GluR
T15090	Decoglurant	RO4995819	GluR
	Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.		GluR
T3479	(RS)-MCPG	alpha-MCPG,(±)-MCPG	GluR
	(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.		GluR
T6022	LY404039	pomaglumetad	Glucocorticoid Receptor , GluR
	LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).		Glucocorticoid Receptor , GluR
T22204	LY 2389575 hydrochloride		Beta Amyloid , GluR
	LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in the level of Mrc1, which amplifi...		Beta Amyloid , GluR
T13318	VU0650786		GluR
	VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents.		GluR
T23000	ML289	VU0463597,ML 289	GluR
	ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 μM), demonstrating over 15-fold selectivity compared to mGlu2 and showing no activity against mGlu5.		GluR
T23003	ML337	ML 337	GluR
	ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.		GluR
T15807	LY2794193		SGLT
	LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).		SGLT
T11906	LY 541850		GluR
	LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expres...		GluR
T15809	LY2812223		LIM Kinase
	LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).		LIM Kinase
T11911	LY3020371 hydrochloride		GluR
	LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks ...		GluR
T38791	LY3020371
	LY3020371 is a highly potent and selective antagonist targeting the glutamate (mGlu) 2/3 receptor, showcasing excellent inhibition at Ki values of 5.26 nM and 2.50 nM for hmGluR2 and hmGluR3, respectively. With its remar...