Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 μM), demonstrating over 15-fold selectivity compared to mGlu2 and showing no activity against mGlu5.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 393.00 | |
100 mg | In stock | $ 593.00 | |
500 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 μM), demonstrating over 15-fold selectivity compared to mGlu2 and showing no activity against mGlu5. |
Targets&IC50 | mGluR3:0.66 μM (IC50) |
In vitro | ML289 (VU0463597) is a central nervous system (CNS)-penetrant probe that functions as a negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3)[1]. |
Synonyms | VU0463597, ML 289 |
Molecular Weight | 349.42 |
Formula | C22H23NO3 |
CAS No. | 1382481-79-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225 mg/mL (643.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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ML289 1382481-79-9 Neuroscience GluR ML-289 VU0463597 ML 289 VU 0463597 VU-0463597 inhibitor inhibit