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LY2812223

Catalog No. T15809 CAS 1311385-20-2

LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).

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LY2812223, CAS 1311385-20-2

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,450.00
50 mg	10-14 weeks	$ 3,190.00
100 mg	10-14 weeks	$ 4,900.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).
Targets&IC50	mGluR3:156 nM (ki), mGluR2:144 nM (ki)

Molecular Weight	284.29
Formula	C10H12N4O4S
CAS No.	1311385-20-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (175.88 mM), Sonification is recommended.

DMSO: 28.75 mg/mL (101.13 mM), Sonification is recommended.

References and Literature

1. Monn JA, et al. Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. J Med Chem. 2015 Sep 24;58(18):7526-48.

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LX7101 SM1-71 BMS-5 BMS-3 T56-LIMKi R-10015 TH-257 LIMK-IN-22j

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LY2812223 1311385-20-2 Cell Cycle/Checkpoint LIM Kinase LY 2812223 LY-2812223 inhibitor inhibit

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