mglur1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3478	Ro 67-7476		GluR
	Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.		GluR
T3479	(RS)-MCPG	alpha-MCPG,(±)-MCPG	GluR
	(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.		GluR
T3483	FTIDC		GluR
	FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibition of FTIDC for mGluR1 receptors is shown to be in noncompe...		GluR
T5512	JNJ16259685	.TN.T 16259685	GluR
	JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 nM.		GluR
T8457	NPS2390		GluR
	NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)		GluR
T29118	VU 0469650	VU0469650,VU 0469650,VU-0469650,VU 0469650 HCl	GluR
	VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).		GluR
T21747	VU0483605		GluR
	VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.		GluR
T10881	CPPHA		GluR
	CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.		GluR
T3482	CFMTI		GluR
	CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 2000-fold than mGluR5.		GluR
T41301	L-Cysteinesulfinic acid monohydrate		GluR
	L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectiv...		GluR
T10432L	AZD-8529 mesylate		GluR
	AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 ...		GluR
T5509	FPTQ		GluR
	FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1]. In addition to its robust inhibitory properties, FPTQ exhibits notable antioxidant ...		GluR
T9021	Ro0711401	Ro-0711401,Ro 0711401	GluR
	Ro0711401 is an agonist of mGlu1 receptor.		GluR
T26486	A-794282
	A-794282 is a selective antagonist of mGluR1.
T9353	OXOMEMAZINE		AChR , Histamine Receptor
	Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low ...		AChR , Histamine Receptor
T25227	CFMMC
	CFMMC is an allosteric mGluR1 antagonist agent.
T27956	LY456066	LY 456066,LY-456066
	LY456066 is a mGluR1 receptor-selective, negative allosteric modulator.
T10432	AZD-8529		Others
	AZD-8529 is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.		Others
T11803	L-Cysteinesulfinic acid		Others
	L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs, pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and ...		Others
T3484	Trans-ACPD	Trans-(±)-ACP,1-amino-1,3-dicarboxycyclopentane,(±)-trans-ACPD	GluR
	trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/1...		GluR